The present application provides novel tetrahydro-isohumulone (THIAA) derivatives and substantially enantiomerically pure compositions and pharmaceutical formulations thereof. The application further provides methods of using the disclosed compounds an compositions to activate PPARγ, inhibit inflammation, and treat conditions associated with inflammation and conditions responsive to PPARγ modulation such as diabetes.
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Date of filing: 9 January 2015; Appl. no. 14/193,164
Applicant information: Kindex Pharmaceuticals, Inc., Seattle, WA, United States
Inventor information: Veera Konda (Bellevue, WA, United States); Jan Urban (Port Orchard, WA, United States); Anuradha Desai (Bellevue, WA, United States); Clinton J. Dahlberg (Port Orchard, WA, United States); & Brian J. Carrol (Gig Harbor, WA, United States)