A systems toxicology investigation comparing and integrating transcriptomic and proteomic results was conducted to develop holistic effects characterizations for the wildlife bird model, Northern bobwhite (Colinus virginianus) dosed with the explosives degradation product 2-amino-4,6-dinitrotoluene (2A-DNT). A subchronic 60d toxicology bioassay was leveraged where both sexes were dosed via daily gavage with 0, 3, 14, or 30 mg/kg-d 2A-DNT. Effects on global transcript expression were investigated in liver and kidney tissue using custom microarrays for C. virginianusin both sexes at all doses, while effects on proteome expression were investigated in liver for both sexes and kidney in males, at 30 mg/kg-d.
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Date of publication: 7 August 2015; BioMed Central Genomics
Author information: Kurt A. Gust; Bindu Nanduri; Arun Rawat; Mitchell S. Wilbanks; Choo Yaw Ang; David R. Johnson; Ken Pendarvis; Xianfeng Chen; Michael J. Quinn Jr.; Mark S. Johnson; Shane C. Burgess; & Edward J. Perkins