ABSTRACT

  • Exposure to certain munitions compounds is know to alter physiological functions in test organisms, however little is known about their molecular and cellular effects.
  • Several nuclear receptors are regulated by xenobiotic compounds. These nuclear receptors belong to a class of ligand-activated transcription factors that, when heterodimerized with RXRa and bound to their respective DNA binding elements, activate gene transcription.
  • Several cell signaling pathways are also affected by xenobiotics, causing dysfunction of normal cellular function and homeostasis.
  • Whole animal experimentation is time and resource intensive and often generates data that is difficult to interpret
  • An initial screening approach would provide detailed mechanistic information that can then be used to guide further in vitro (cell culture) and in vivo (animal) experiments
  • The objective of this study was to characterize the effects of new and existing munitions compounds on xenobiotic-activated nuclear receptor and transcription factor pathways in order to better identify potential molecular initiating events that may result in toxicity.

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Source of publication: ERDC: Engineer Research and Development Center

Author information: David R. Johnson (1); ChooYaw Ang (2); Tanwir Habib (2); & Edward J. Perkins (1)

(1) Environmental Laboratory, US Army Engineer Research and Development Center, Vicksburg, MS
(2) Badger Technical Services, Vicksburg, MS

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