| URN | urn:agi-llid:3567 |
|---|---|
| Connectivity | 696 |
| Name | IL5 |
| Description | interleukin 5 (colony-stimulating factor, eosinophil) |
| Notes | The protein encoded by this gene is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. This cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of this cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. This cytokine, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq] |
| Pathway | IL5R -> STAT signaling |
|---|---|
| IL5R -> SOX4 signaling | |
| PPARA Targets | |
| PPARG Targets | |
| GR Targets |
| Ariadne Ontology | Cytokine |
|---|
| GO Molecular Function | growth factor activity |
|---|---|
| cytokine activity | |
| interleukin-5 receptor binding |
| GO Cellular Component | extracellular region |
|---|---|
| soluble fraction | |
| extracellular space |
| GO Biological Process | positive regulation of cell proliferation |
|---|---|
| positive regulation of B cell proliferation | |
| positive regulation of JAK-STAT cascade | |
| positive regulation of eosinophil differentiation | |
| positive regulation of peptidyl-tyrosine phosphorylation | |
| cytokine-mediated signaling pathway | |
| immune response | |
| inflammatory response |
| Group | Cytokine |
|---|---|
| extracellular region | |
| soluble fraction | |
| extracellular space | |
| growth factor activity | |
| cytokine activity | |
| interleukin-5 receptor binding | |
| positive regulation of cell proliferation | |
| positive regulation of B cell proliferation | |
| positive regulation of JAK-STAT cascade | |
| positive regulation of eosinophil differentiation | |
| positive regulation of peptidyl-tyrosine phosphorylation | |
| cytokine-mediated signaling pathway | |
| immune response | |
| inflammatory response |
| Hugo ID | 6016 |
|---|
| Human chromosome position | 5q31.1 |
|---|
| LocusLink ID | 3567 |
|---|---|
| 16191 | |
| 24497 |
| Alias | EDF |
|---|---|
| TRF | |
| IL-5 | |
| interleukin 5 | |
| interleukin-5 | |
| OTTHUMP00000065830 | |
| T-cell replacing factor | |
| B cell differentiation factor I | |
| eosinophil differentiation factor | |
| RP23-239O19.2 | |
| OTTMUSP00000005818 | |
| Interleukin 5 (colony-stimulating factor eosinophil) | |
| Interleukin 5 (colony-stimulating factor, eosinophil) | |
| B cell differentiation factor I | |
| eosinophil colony-stimulating factor | |
| IL5_HUMAN | |
| interleukin IL5 | |
| Interleukin-5 precursor | |
| eosinophil colony-stimulation factor | |
| interleukin 5 (colony-stimulation factor, eosinophil) | |
| IL5 | |
| B cell differentiating factor I | |
| B cell differentiating factor 1 | |
| Eosinophil differentiating factor |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 147850 |
|---|
| Swiss-Prot Accession | P05113 |
|---|---|
| P04401 | |
| Q5SV01 | |
| Q05A89 | |
| Q62349 | |
| Q9R2C9 | |
| Q08125 |
| Unigene ID | Hs.2247 |
|---|---|
| Mm.4461 | |
| Rn.44227 |
| KEGG ID | hsa:3567 |
|---|---|
| mmu:16191 | |
| rno:24497 |
| Swiss-Prot ID | IL5_HUMAN |
|---|---|
| IL5_MOUSE | |
| Q5SV01_MOUSE | |
| Q9R2C9_RAT |
| Cell Localization | Extracellular |
|---|
| GO ID | 0005125 |
|---|---|
| 0005137 | |
| 0006955 | |
| 0006954 | |
| 0050731 | |
| 0005576 | |
| 0005615 | |
| 0008083 | |
| 0019221 | |
| 0030890 | |
| 0046427 | |
| 0008284 | |
| 0045645 | |
| 0005625 |
| IPI ID | IPI00007082 |
|---|---|
| IPI00796601 | |
| IPI00115757 | |
| IPI00459460 | |
| IPI00197557 |
| Mouse chromosome position | 11 29.2 cM |
|---|
| Homologene ID | 679 |
|---|
| MGI ID | 96557 |
|---|
| Rat chromosome position | 10q22 |
|---|
| RGD ID | 2900 |
|---|