| URN | urn:agi-llid:2147 |
|---|---|
| Connectivity | 1628 |
| Name | F2 |
| Description | coagulation factor II (thrombin) |
| Notes | Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia. [provided by RefSeq] |
| Pathway | ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling |
|---|---|
| ThrombinR -> STAT1 signaling | |
| ThrombinR -> NF-kB signaling | |
| Common Regulators | |
| PPARG Targets | |
| HNF4A Targets |
| Ariadne Ontology | Coagulation factor |
|---|
| GO Molecular Function | calcium ion binding |
|---|---|
| receptor binding | |
| hydrolase activity | |
| peptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity | |
| receptor activity | |
| thrombospondin receptor activity |
| GO Cellular Component | extracellular region |
|---|---|
| soluble fraction | |
| plasma membrane | |
| extracellular space |
| GO Biological Process | fibrinolysis |
|---|---|
| release of sequestered calcium ion into cytosol | |
| positive regulation of collagen biosynthetic process | |
| positive regulation of blood coagulation | |
| activation of caspase activity | |
| cell surface receptor linked signal transduction | |
| STAT protein nuclear translocation | |
| tyrosine phosphorylation of STAT protein | |
| blood coagulation | |
| platelet activation | |
| apoptosis | |
| multicellular organismal development | |
| proteolysis | |
| response to stress | |
| response to wounding | |
| wound healing | |
| acute-phase response |
| Group | Coagulation factor |
|---|---|
| extracellular region | |
| soluble fraction | |
| plasma membrane | |
| extracellular space | |
| calcium ion binding | |
| receptor binding | |
| hydrolase activity | |
| peptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity | |
| receptor activity | |
| thrombospondin receptor activity | |
| fibrinolysis | |
| release of sequestered calcium ion into cytosol | |
| positive regulation of collagen biosynthetic process | |
| positive regulation of blood coagulation | |
| activation of caspase activity | |
| cell surface receptor linked signal transduction | |
| STAT protein nuclear translocation | |
| tyrosine phosphorylation of STAT protein | |
| blood coagulation | |
| platelet activation | |
| apoptosis | |
| multicellular organismal development | |
| proteolysis | |
| response to stress | |
| response to wounding | |
| wound healing | |
| acute-phase response |
| Hugo ID | 3535 |
|---|
| Human chromosome position | 11p11 |
|---|
| LocusLink ID | 2147 |
|---|---|
| 14061 | |
| 29251 |
| Alias | PT |
|---|---|
| coagulation factor II | |
| serine protease | |
| prothrombin B-chain | |
| Cf2 | |
| FII | |
| Cf-2 | |
| RP23-176N9.4 | |
| prothrombin | |
| coagulation factor 2 | |
| prothrombin b | |
| THRB_HUMAN | |
| blood-coagulating factor iias | |
| coagulating factor II (thrombin) | |
| thrombases | |
| activated blood-coagulating factor II | |
| activated blood-coagulating factor 2 | |
| activated blood-coagulating factor iis | |
| blood-coagulating factor IIa | |
| activated blood-coagulation factor II | |
| coagulation factor II (thrombin) | |
| g-thrombin | |
| beta-thrombin | |
| blood-coagulation factor IIa | |
| factor IIa | |
| fibrinogenase | |
| thrombase | |
| thrombofort | |
| tropostasin | |
| thrombin | |
| thrombins | |
| thrombin activity | |
| E thrombin | |
| thrombin-C | |
| beta-thrombins | |
| g-thrombins | |
| tropostasins | |
| E thrombins | |
| fibrinogenases |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 176930 |
|---|
| Swiss-Prot Accession | P00734 |
|---|---|
| Q15253 | |
| Q16505 | |
| Q4QZ40 | |
| Q53H04 | |
| Q53H06 | |
| Q69EZ7 | |
| Q69EZ8 | |
| Q7Z7P3 | |
| Q86WA1 | |
| Q8TD58 | |
| P19221 | |
| Q3TJ94 | |
| P18292 |
| Unigene ID | Hs.655207 |
|---|---|
| Mm.89048 | |
| Rn.54498 |
| KEGG ID | rno:29251 |
|---|
| EC Number | 3.4.21.5 |
|---|
| Swiss-Prot ID | THRB_HUMAN |
|---|---|
| THRB_MOUSE | |
| Q3TJ94_MOUSE |
| Cell Localization | Extracellular |
|---|
| GO ID | 0005509 |
|---|---|
| 0008233 | |
| 0005102 | |
| 0004252 | |
| 0070053 | |
| 0007262 | |
| 0006919 | |
| 0006953 | |
| 0006915 | |
| 0007166 | |
| 0042730 | |
| 0007275 | |
| 0030168 | |
| 0030194 | |
| 0032967 | |
| 0006508 | |
| 0051209 | |
| 0009611 | |
| 0007260 | |
| 0005576 | |
| 0005615 | |
| 0005886 | |
| 0005625 | |
| 0016787 | |
| 0008236 | |
| 0007596 | |
| 0004872 | |
| 0006950 | |
| 0042060 |
| IPI ID | IPI00019568 |
|---|---|
| IPI00816612 | |
| IPI00877967 | |
| IPI00114206 | |
| IPI00189981 |
| Mouse chromosome position | 2 47.5 cM |
|---|
| Homologene ID | 426 |
|---|
| MGI ID | 88380 |
|---|
| Rat chromosome position | 3q24 |
|---|
| RGD ID | 61996 |
|---|