| URN | urn:agi-llid:6439 |
|---|---|
| Connectivity | 119 |
| Name | SFTPB |
| Description | surfactant protein B |
| Notes | The SFTPB gene encodes the pulmonary-associated surfactant B protein (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a lipid-rich material that prevents lung collapse by lowering surface tension at the air-liquid interface in the alveoli of lung. SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Surfactant is composed of phospholipids and other surfactant-associated proteins (Clark et al., 1995 [PubMed 7644495]). See also SFTPA1 (MIM 178630), SFTPC (MIM 178620), and SFTPD (MIM 178635).[supplied by OMIM] |
| Pathway | RARA Targets |
|---|---|
| PPARG Targets |
| GO Molecular Function | molecular_function |
|---|
| GO Cellular Component | extracellular region |
|---|---|
| lysosome | |
| extracellular space |
| GO Biological Process | regulation of liquid surface tension |
|---|---|
| sphingolipid metabolic process | |
| organ morphogenesis | |
| lipid metabolic process | |
| respiratory gaseous exchange |
| Group | extracellular region |
|---|---|
| lysosome | |
| extracellular space | |
| molecular_function | |
| regulation of liquid surface tension | |
| sphingolipid metabolic process | |
| organ morphogenesis | |
| lipid metabolic process | |
| respiratory gaseous exchange |
| Hugo ID | 10801 |
|---|
| Human chromosome position | 2p12-p11.2 |
|---|
| LocusLink ID | 6439 |
|---|---|
| 20388 | |
| 192155 |
| Alias | SP-B |
|---|---|
| PSP-B | |
| SFTB3 | |
| SFTP3 | |
| SMDP1 | |
| surfactant, pulmonary-associated protein B | |
| Pulmonary surfactant-associated protein B, 18kD | |
| SF-B | |
| Sftp-3 | |
| AI562151 | |
| surfactant associated protein B | |
| surfactant protein B | |
| surfactant pulmonary-associated protein B | |
| 18 kDa pulmonary-surfactant protein | |
| 18 kDa Pulmonary surfactant-associated protein B | |
| Pulmonary surfactant-associated protein B | |
| SFTPB | |
| Pulmonary surfactant-associated proteolipid SPL | |
| pulmonary-surfactant protein B |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 178640 |
|---|---|
| 265120 |
| Swiss-Prot Accession | P07988 |
|---|---|
| P50405 | |
| P22355 | |
| Q6IN44 |
| Unigene ID | Hs.512690 |
|---|---|
| Mm.46033 | |
| Rn.1952 |
| KEGG ID | hsa:6439 |
|---|---|
| mmu:20388 | |
| rno:192155 |
| Swiss-Prot ID | PSPB_HUMAN |
|---|---|
| PSPB_MOUSE | |
| PSPB_RAT |
| GO ID | 0006629 |
|---|---|
| 0009887 | |
| 0050828 | |
| 0007585 | |
| 0006665 | |
| 0005576 | |
| 0005615 | |
| 0005764 | |
| 0003674 |
| IPI ID | IPI00296083 |
|---|---|
| IPI00117977 | |
| IPI00720119 | |
| IPI00206151 |
| Mouse chromosome position | 6 31.0 cM |
|---|
| Homologene ID | 456 |
|---|
| MGI ID | 109516 |
|---|
| Rat chromosome position | 4q33 |
|---|
| RGD ID | 621700 |
|---|