Protein IL8

URN	urn:agi-llid:3576
Connectivity	1825
Name	IL8
Description	interleukin 8
Notes	The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq]

Pathway	CCR5 -> TP53 signaling
	CCR2/5 -> STAT signaling
	Common Regulators
	RARA Targets
	PPARA Targets
	PPARD Targets
	PPARG Targets
	RORA Targets
	VDR Targets
	NR2F2 Targets
	ERA Pathway
	GR Targets
	Common Regulators and Small Molecules

Ariadne Ontology	Chemokines

GO Molecular Function	protein binding
	interleukin-8 receptor binding
	chemokine activity

GO Cellular Component	extracellular region
	extracellular space

GO Biological Process	angiogenesis
	regulation of cell adhesion
	negative regulation of cell proliferation
	induction of positive chemotaxis
	intracellular signaling cascade
	G-protein coupled receptor protein signaling pathway
	calcium-mediated signaling
	regulation of retroviral genome replication
	cell motion
	neutrophil activation
	cell-cell signaling
	cell cycle arrest
	neutrophil chemotaxis
	immune response
	chemotaxis
	inflammatory response

Group	Chemokines
	extracellular region
	extracellular space
	protein binding
	interleukin-8 receptor binding
	chemokine activity
	angiogenesis
	regulation of cell adhesion
	negative regulation of cell proliferation
	induction of positive chemotaxis
	intracellular signaling cascade
	G-protein coupled receptor protein signaling pathway
	calcium-mediated signaling
	regulation of retroviral genome replication
	cell motion
	neutrophil activation
	cell-cell signaling
	cell cycle arrest
	neutrophil chemotaxis
	immune response
	chemotaxis
	inflammatory response

Hugo ID	6025

Human chromosome position	4q13-q21

LocusLink ID	3576

Alias	NAF
	GCP1
	LECT
	LUCT
	NAP1
	CXCL8
	GCP-1
	LYNAP
	MDNCF
	MONAP
	NAP-1
	interleukin 8
	emoctakin
	T cell chemotactic factor
	neutrophil-activating peptide 1
	chemokine (C-X-C motif) ligand 8
	beta-thromboglobulin-like protein
	granulocyte chemotactic protein 1
	monocyte-derived neutrophil chemotactic factor
	small inducible cytokine subfamily B, member 8
	lymphocyte-derived neutrophil-activating factor
	3-10C
	AMCF-I
	b-ENAP
	IL8_HUMAN
	Interleukin-IL8
	Lymphocyte-derived neutrophil- activating factor
	monocyte derived neutrophil-activating protein
	Neutrophil- activating protein 1
	Neutrophil-activating factor
	CXC chemokine ligand VIII
	interleukin VIII
	LUCT/interleukin-8
	neutrophil-activating peptide I
	SCYB8
	GCP I
	IL VIII
	IL VIIIs
	CXC chemokine ligand 8
	T-cell chemotactic factor
	IL8
	Granulocyte chemotactic protein I
	IL[8]
	small inducible cytokine subfamily B, member VIII
	Neutrophil- activating protein I
	LOC133094

Organism	Homo sapiens

OMIM ID	146930

Swiss-Prot Accession	P10145

Unigene ID	Hs.624

KEGG ID	hsa:3576

Swiss-Prot ID	IL8_HUMAN

Cell Localization	Extracellular