| URN | urn:agi-llid:929 |
|---|---|
| Connectivity | 475 |
| Name | CD14 |
| Description | CD14 molecule |
| Notes | CD14 is a surface protein preferentially expressed on monocytes/macrophages. It binds lipopolysaccharide binding protein and recently has been shown to bind apoptotic cells. Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq] |
| Pathway | TLR4/5/7/9 -> NF-kB signaling |
|---|---|
| TLR -> AP-1 signaling | |
| TLR4 -> IRF signaling | |
| PPARG Targets | |
| VDR Targets |
| Ariadne Ontology | TLR |
|---|
| GO Molecular Function | protein binding |
|---|---|
| peptidoglycan receptor activity | |
| opsonin receptor activity |
| GO Cellular Component | extracellular region |
|---|---|
| membrane | |
| plasma membrane | |
| lipopolysaccharide receptor complex | |
| membrane raft | |
| anchored to membrane |
| GO Biological Process | cell surface receptor linked signal transduction |
|---|---|
| apoptosis | |
| phagocytosis | |
| immune response | |
| response to molecule of bacterial origin | |
| inflammatory response |
| Group | TLR |
|---|---|
| extracellular region | |
| membrane | |
| plasma membrane | |
| lipopolysaccharide receptor complex | |
| membrane raft | |
| anchored to membrane | |
| protein binding | |
| peptidoglycan receptor activity | |
| opsonin receptor activity | |
| cell surface receptor linked signal transduction | |
| apoptosis | |
| phagocytosis | |
| immune response | |
| response to molecule of bacterial origin | |
| inflammatory response |
| Hugo ID | 1628 |
|---|
| Human chromosome position | 5q22-q32 |
|---|
| LocusLink ID | 929 |
|---|---|
| 12475 | |
| 60350 |
| Alias | CD14 antigen |
|---|---|
| monocyte differentiation antigen CD14 | |
| CD14 molecule | |
| Monocyte differentiating antigen CD14 precursor | |
| CD14_HUMAN | |
| LPS-R | |
| monocyte surface glycoprotein CD14 precursor | |
| Myeloid cell-specific leucine-rich glycoprotein | |
| Monocyte differentiation antigen CD14 precursor | |
| CD14 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 158120 |
|---|
| Swiss-Prot Accession | P08571 |
|---|---|
| Q53XT5 | |
| P10810 | |
| Q4FJP7 | |
| Q3TE16 | |
| Q3U6A3 | |
| Q3UB18 | |
| Q3UE54 | |
| Q91V69 | |
| Q91VC2 | |
| Q91VD3 | |
| Q920X7 | |
| Q920X8 | |
| Q920X9 | |
| Q63691 | |
| O88955 |
| Unigene ID | Hs.163867 |
|---|---|
| Mm.3460 | |
| Rn.42942 |
| KEGG ID | hsa:929 |
|---|---|
| mmu:12475 | |
| rno:60350 |
| Swiss-Prot ID | CD14_HUMAN |
|---|---|
| CD14_MOUSE | |
| CD14_RAT | |
| Q4FJP7_MOUSE |
| Cell Localization | Plasma membrane |
|---|
| GO ID | 0001847 |
|---|---|
| 0016019 | |
| 0005515 | |
| 0006915 | |
| 0007166 | |
| 0006955 | |
| 0006954 | |
| 0006909 | |
| 0002237 | |
| 0031225 | |
| 0005576 | |
| 0046696 | |
| 0045121 | |
| 0005886 | |
| 0016020 |
| IPI ID | IPI00029260 |
|---|---|
| IPI00308990 | |
| IPI00231949 |
| Mouse chromosome position | 18 31.0 cM |
|---|
| Homologene ID | 493 |
|---|
| MGI ID | 88318 |
|---|
| Rat chromosome position | 18p11 |
|---|
| RGD ID | 620588 |
|---|