| URN | urn:agi-llid:356 |
|---|---|
| Connectivity | 911 |
| Name | FASLG |
| Description | Fas ligand (TNF superfamily, member 6) |
| Notes | The protein encoded by this gene is the ligand for FAS. Both are transmembrane proteins. Interaction of FAS with this ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). [provided by RefSeq] |
| Pathway | TNFRSF6 -> HSF1 signaling |
|---|---|
| TNFRSF6 -> FOXO3A signaling | |
| TNFRSF6 -> DDIT3 signaling | |
| TNFR -> NF-kB signaling | |
| TNFR -> AP-1/ATF/TP53 signaling | |
| TNFRSF5/6 -> RB1/E2F signaling | |
| TNFR -> CREB/ELK-SRF signaling | |
| RARA Targets | |
| PPARG Targets | |
| RORG Targets | |
| VDR Targets | |
| ERA Pathway | |
| GR Targets | |
| AR Targets | |
| TR3 Targets |
| Ariadne Ontology | TNF family |
|---|
| GO Molecular Function | cytokine activity |
|---|---|
| death receptor binding | |
| tumor necrosis factor receptor binding |
| GO Cellular Component | extracellular region |
|---|---|
| membrane | |
| external side of plasma membrane | |
| perinuclear region of cytoplasm | |
| cytoplasmic membrane-bounded vesicle | |
| plasma membrane | |
| membrane raft | |
| integral to membrane | |
| integral to plasma membrane | |
| caveola | |
| extracellular space |
| GO Biological Process | positive regulation of I-kappaB kinase-NF-kappaB cascade |
|---|---|
| positive regulation of apoptosis | |
| induction of apoptosis by extracellular signals | |
| induction of apoptosis via death domain receptors | |
| activation of pro-apoptotic gene products | |
| signal transduction | |
| cell-cell signaling | |
| apoptosis | |
| inflammatory cell apoptosis | |
| retinal cell programmed cell death | |
| immune response | |
| response to lipopolysaccharide |
| Group | TNF family |
|---|---|
| extracellular region | |
| membrane | |
| external side of plasma membrane | |
| perinuclear region of cytoplasm | |
| cytoplasmic membrane-bounded vesicle | |
| plasma membrane | |
| membrane raft | |
| integral to membrane | |
| integral to plasma membrane | |
| caveola | |
| extracellular space | |
| cytokine activity | |
| death receptor binding | |
| tumor necrosis factor receptor binding | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of apoptosis | |
| induction of apoptosis by extracellular signals | |
| induction of apoptosis via death domain receptors | |
| activation of pro-apoptotic gene products | |
| signal transduction | |
| cell-cell signaling | |
| apoptosis | |
| inflammatory cell apoptosis | |
| retinal cell programmed cell death | |
| immune response | |
| response to lipopolysaccharide |
| Hugo ID | 11936 |
|---|
| Human chromosome position | 1q23 |
|---|
| LocusLink ID | 356 |
|---|---|
| 14103 | |
| 25385 |
| Alias | FASL |
|---|---|
| CD178 | |
| CD95L | |
| TNFSF6 | |
| APT1LG1 | |
| fas ligand | |
| CD95 ligand | |
| OTTHUMP00000032708 | |
| apoptosis (APO-1) antigen ligand 1 | |
| tumor necrosis factor (ligand) superfamily, member 6 | |
| gld | |
| Fas-L | |
| Faslg | |
| Fas-Ligand | |
| Fas ligand (TNF superfamily, member 6) | |
| Fas antigen ligand | |
| generalized lymphoproliferative disease | |
| Apoptosis (APO-1) antigen ligand 1 (Fas antigen ligand) | |
| Tumor necrosis factor (ligand) superfamily member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand) | |
| Tumor necrosis factor (ligand) superfamily, member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand) | |
| Apo1 ligand | |
| Apoptosis antigen ligand | |
| APTL | |
| CD178 antigen | |
| FAS L | |
| TNF6 | |
| TNF6_HUMAN | |
| tumor necrosis factor (ligand) superfamily, member VI | |
| apoptosis (APO-1) antigen ligand I | |
| APT1LG I | |
| tumor necrosis factor (ligand) superfamily member 6 (apoptosis | |
| Tnfsf6s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 134638 |
|---|---|
| 152700 |
| Swiss-Prot Accession | P48023 |
|---|---|
| Q53ZZ1 | |
| Q0VHD7 | |
| P41047 | |
| Q544E9 | |
| Q7TMV9 | |
| Q99PH8 | |
| P36940 |
| Unigene ID | Hs.2007 |
|---|---|
| Mm.3355 | |
| Rn.9725 |
| KEGG ID | hsa:356 |
|---|---|
| rno:25385 |
| Swiss-Prot ID | TNFL6_HUMAN |
|---|---|
| TNFL6_MOUSE | |
| TNFL6_RAT | |
| Q53ZZ1_HUMAN | |
| Q544E9_MOUSE |
| Cell Localization | Extracellular |
|---|
| GO ID | 0005125 |
|---|---|
| 0005164 | |
| 0008633 | |
| 0007267 | |
| 0006955 | |
| 0008624 | |
| 0043123 | |
| 0007165 | |
| 0005576 | |
| 0005615 | |
| 0005887 | |
| 0005886 | |
| 0006915 | |
| 0043065 | |
| 0046666 | |
| 0009897 | |
| 0016021 | |
| 0016020 | |
| 0005123 | |
| 0008625 | |
| 0006925 | |
| 0032496 | |
| 0005901 | |
| 0016023 | |
| 0045121 | |
| 0048471 |
| IPI ID | IPI00007577 |
|---|---|
| IPI00220870 | |
| IPI00110272 | |
| IPI00227798 | |
| IPI00462905 | |
| IPI00326685 | |
| IPI00781706 |
| Mouse chromosome position | 1 85.0 cM |
|---|
| Homologene ID | 533 |
|---|
| MGI ID | 99255 |
|---|
| Rat chromosome position | 13q22 |
|---|
| RGD ID | 3880 |
|---|