| URN | urn:agi-llid:6776 |
|---|---|
| Connectivity | 738 |
| Name | STAT5A |
| Description | signal transducer and activator of transcription 5A |
| Notes | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. [provided by RefSeq] |
| Pathway | LIFR -> STAT5A signaling |
|---|---|
| MPL -> STAT signaling | |
| ErythropoietinR -> STAT signaling | |
| CSF3R -> STAT signaling | |
| IFNGR -> STAT signaling | |
| LeptinR -> STAT signaling | |
| CSF2R -> STAT signaling | |
| ProlactinR -> STAT signaling | |
| GHR -> STAT signaling | |
| IL21R -> STAT signaling | |
| IL15R -> STAT signaling | |
| IL10R -> STAT signaling | |
| IL7R -> STAT signaling | |
| IL2R -> STAT signaling | |
| IL5R -> STAT signaling | |
| IL13R -> STAT signaling | |
| IL12R -> STAT signaling | |
| IL9R -> STAT signaling | |
| IL31R -> STAT signaling | |
| IL4R -> STAT signaling | |
| IL3R -> STAT signaling | |
| CCR2/5 -> STAT signaling | |
| CXCR4 -> STAT signaling | |
| PECAM -> STAT signaling | |
| EphrinR -> STAT signaling | |
| AngiopoietinR -> STAT signaling | |
| HGFR -> STAT signaling | |
| EGFR/ERBB -> STAT signaling | |
| FGFR3 -> STAT signaling | |
| FGFR1 -> STAT signaling | |
| KIT -> STAT signaling | |
| InsulinR -> STAT signaling | |
| IGF1R -> STAT signaling | |
| T-cell receptor -> STAT signaling | |
| CD2 -> STAT signaling | |
| TNFRSF5 -> STAT signaling | |
| TNFRSF1A -> STAT signaling | |
| Common Regulators | |
| PPARG Targets | |
| GR Targets | |
| PGR Targets |
| Ariadne Ontology | STAT |
|---|
| GO Molecular Function | protein binding |
|---|---|
| phosphate binding | |
| calcium ion binding | |
| DNA binding | |
| sequence-specific DNA binding | |
| transcription factor activity | |
| double-stranded DNA binding | |
| signal transducer activity |
| GO Cellular Component | cytoplasm |
|---|---|
| nucleus |
| GO Biological Process | regulation of cell adhesion |
|---|---|
| negative regulation of apoptosis | |
| positive regulation of survival gene product expression | |
| negative regulation of erythrocyte differentiation | |
| positive regulation of cell proliferation | |
| positive regulation of lymphocyte differentiation | |
| positive regulation of B cell differentiation | |
| positive regulation of gamma-delta T cell differentiation | |
| positive regulation of activated T cell proliferation | |
| positive regulation of mitotic cell cycle | |
| positive regulation of interleukin-2 biosynthetic process | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of multicellular organism growth | |
| positive regulation of inflammatory response | |
| signal transduction | |
| regulation of epithelial cell differentiation | |
| regulation of steroid metabolic process | |
| regulation of transcription, DNA-dependent | |
| regulation of transcription from RNA polymerase II promoter | |
| cytokine-mediated signaling pathway | |
| JAK-STAT cascade involved in growth hormone signaling pathway | |
| JAK-STAT cascade | |
| T cell homeostasis | |
| natural killer cell differentiation | |
| T cell differentiation in the thymus | |
| taurine metabolic process | |
| creatine metabolic process | |
| creatinine metabolic process | |
| isoleucine metabolic process | |
| valine metabolic process | |
| transcription | |
| transcription from RNA polymerase II promoter | |
| 2-oxoglutarate metabolic process | |
| fatty acid metabolic process | |
| peptidyl-tyrosine phosphorylation | |
| allantoin metabolic process | |
| citrate metabolic process | |
| succinate metabolic process | |
| oxaloacetate metabolic process | |
| mammary gland involution | |
| mammary gland development | |
| lactation | |
| luteinization | |
| Peyer's patch development | |
| development of secondary female sexual characteristics | |
| development of secondary male sexual characteristics | |
| lipid storage | |
| female pregnancy | |
| reproductive process in a multicellular organism | |
| response to peptide hormone stimulus | |
| response to ethanol | |
| response to nutrient levels |
| Group | STAT |
|---|---|
| cytoplasm | |
| nucleus | |
| protein binding | |
| phosphate binding | |
| calcium ion binding | |
| DNA binding | |
| sequence-specific DNA binding | |
| transcription factor activity | |
| double-stranded DNA binding | |
| signal transducer activity | |
| regulation of cell adhesion | |
| negative regulation of apoptosis | |
| positive regulation of survival gene product expression | |
| negative regulation of erythrocyte differentiation | |
| positive regulation of cell proliferation | |
| positive regulation of lymphocyte differentiation | |
| positive regulation of B cell differentiation | |
| positive regulation of gamma-delta T cell differentiation | |
| positive regulation of activated T cell proliferation | |
| positive regulation of mitotic cell cycle | |
| positive regulation of interleukin-2 biosynthetic process | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of multicellular organism growth | |
| positive regulation of inflammatory response | |
| signal transduction | |
| regulation of epithelial cell differentiation | |
| regulation of steroid metabolic process | |
| regulation of transcription, DNA-dependent | |
| regulation of transcription from RNA polymerase II promoter | |
| cytokine-mediated signaling pathway | |
| JAK-STAT cascade involved in growth hormone signaling pathway | |
| JAK-STAT cascade | |
| T cell homeostasis | |
| natural killer cell differentiation | |
| T cell differentiation in the thymus | |
| taurine metabolic process | |
| creatine metabolic process | |
| creatinine metabolic process | |
| isoleucine metabolic process | |
| valine metabolic process | |
| transcription | |
| transcription from RNA polymerase II promoter | |
| 2-oxoglutarate metabolic process | |
| fatty acid metabolic process | |
| peptidyl-tyrosine phosphorylation | |
| allantoin metabolic process | |
| citrate metabolic process | |
| succinate metabolic process | |
| oxaloacetate metabolic process | |
| mammary gland involution | |
| mammary gland development | |
| lactation | |
| luteinization | |
| Peyer's patch development | |
| development of secondary female sexual characteristics | |
| development of secondary male sexual characteristics | |
| lipid storage | |
| female pregnancy | |
| reproductive process in a multicellular organism | |
| response to peptide hormone stimulus | |
| response to ethanol | |
| response to nutrient levels |
| Hugo ID | 11366 |
|---|
| Human chromosome position | 17q11.2 |
|---|
| LocusLink ID | 6776 |
|---|---|
| 20850 | |
| 24918 |
| Alias | MGF |
|---|---|
| STAT5 | |
| signal transducer and activator of transcription 5A | |
| AA959963 | |
| RP23-279L23.4 | |
| OTTMUSP00000002045 | |
| OTTMUSP00000002046 | |
| STAT5a variant delta E18 | |
| mammary gland factor STAT5A | |
| signal transducer and activator of transcription 5 | |
| Stat5a | |
| STAT V |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601511 |
|---|
| Swiss-Prot Accession | P42229 |
|---|---|
| Q1KLZ6 | |
| Q59GY7 | |
| Q8WWS9 | |
| P42230 | |
| Q9JIA0 | |
| Q3UZ79 | |
| Q6PHA0 | |
| Q71UV3 | |
| Q9R0X9 | |
| Q62771 |
| Unigene ID | Hs.437058 |
|---|---|
| Mm.277403 | |
| Rn.154399 |
| KEGG ID | mmu:20850 |
|---|---|
| rno:24918 |
| Swiss-Prot ID | STA5A_HUMAN |
|---|---|
| STA5A_MOUSE | |
| STA5A_RAT | |
| Q9JIA0_MOUSE |
| Cell Localization | Nucleus |
|---|
| GO ID | 0005509 |
|---|---|
| 0042301 | |
| 0005515 | |
| 0004871 | |
| 0003700 | |
| 0006103 | |
| 0007259 | |
| 0048541 | |
| 0033077 | |
| 0043029 | |
| 0000255 | |
| 0006101 | |
| 0006600 | |
| 0046449 | |
| 0019221 | |
| 0046543 | |
| 0046544 | |
| 0006631 | |
| 0007565 | |
| 0006549 | |
| 0007595 | |
| 0019915 | |
| 0001553 | |
| 0030879 | |
| 0001779 | |
| 0043066 | |
| 0045647 | |
| 0006107 | |
| 0018108 | |
| 0045579 | |
| 0042104 | |
| 0008284 | |
| 0045588 | |
| 0050729 | |
| 0045086 | |
| 0045931 | |
| 0040018 | |
| 0045885 | |
| 0045944 | |
| 0030155 | |
| 0030856 | |
| 0019218 | |
| 0043434 | |
| 0007165 | |
| 0006105 | |
| 0019530 | |
| 0006573 | |
| 0005737 | |
| 0005634 | |
| 0003677 | |
| 0060397 | |
| 0045621 | |
| 0006357 | |
| 0006355 | |
| 0006350 | |
| 0003690 | |
| 0043565 | |
| 0060056 | |
| 0048609 | |
| 0045471 | |
| 0031667 | |
| 0006366 |
| IPI ID | IPI00030783 |
|---|---|
| IPI00878538 | |
| IPI00114979 | |
| IPI00894610 | |
| IPI00649213 | |
| IPI00649294 | |
| IPI00208241 | |
| IPI00231852 |
| Mouse chromosome position | 11 60.5 cM |
|---|
| Homologene ID | 20680 |
|---|
| MGI ID | 103036 |
|---|
| Rat chromosome position | 10q32.1 |
|---|
| RGD ID | 3773 |
|---|