| URN | urn:agi-llid:5327 |
|---|---|
| Connectivity | 767 |
| Name | PLAT |
| Description | plasminogen activator, tissue |
| Notes | This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq] |
| Pathway | RARA Targets |
|---|---|
| RARB Targets | |
| PPARG Targets |
| Ariadne Ontology | PLA |
|---|
| GO Molecular Function | hydrolase activity |
|---|---|
| peptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity |
| GO Cellular Component | extracellular region |
|---|---|
| synapse | |
| apical part of cell | |
| cytoplasm | |
| secretory granule | |
| cytoskeleton | |
| extracellular space |
| GO Biological Process | regulation of synaptic plasticity |
|---|---|
| platelet-derived growth factor receptor signaling pathway | |
| blood coagulation | |
| synaptic transmission, glutamatergic | |
| smooth muscle cell migration | |
| protein modification process | |
| blood vessel morphogenesis | |
| proteolysis | |
| response to hypoxia |
| Group | PLA |
|---|---|
| extracellular region | |
| synapse | |
| apical part of cell | |
| cytoplasm | |
| secretory granule | |
| cytoskeleton | |
| extracellular space | |
| hydrolase activity | |
| peptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity | |
| regulation of synaptic plasticity | |
| platelet-derived growth factor receptor signaling pathway | |
| blood coagulation | |
| synaptic transmission, glutamatergic | |
| smooth muscle cell migration | |
| protein modification process | |
| blood vessel morphogenesis | |
| proteolysis | |
| response to hypoxia |
| Hugo ID | 9051 |
|---|
| Human chromosome position | 8p12 |
|---|
| LocusLink ID | 5327 |
|---|---|
| 18791 | |
| 25692 |
| Alias | TPA |
|---|---|
| T-PA | |
| DKFZp686I03148 | |
| plasminogen activator, tissue | |
| alteplase | |
| reteplase | |
| t-plasminogen activator | |
| plasminogen activator, tissue type | |
| tissue plasminogen activator (t-PA) | |
| AU020998 | |
| AW212668 | |
| D8Ertd2e | |
| MGC18508 | |
| PATISS | |
| tissue plasminogen activator | |
| tissue-type plasminogen activator precursor | |
| reteplases | |
| anistreplase | |
| anistreplases | |
| alteplases | |
| PLAT protein | |
| protein PLAT | |
| PLAT | |
| tissue PA | |
| plasminogen tissue activator |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 173370 |
|---|---|
| 612348 |
| Swiss-Prot Accession | P00750 |
|---|---|
| B2R8E8 | |
| Q5HYM8 | |
| Q6LBF5 | |
| P11214 | |
| P19637 |
| Unigene ID | Hs.491582 |
|---|---|
| Mm.154660 | |
| Mm.477132 | |
| Rn.107102 |
| KEGG ID | hsa:5327 |
|---|---|
| rno:25692 |
| EC Number | 3.4.21.68 |
|---|
| Swiss-Prot ID | TPA_HUMAN |
|---|---|
| TPA_MOUSE | |
| TPA_RAT | |
| B2R8E8_HUMAN |
| Cell Localization | Extracellular |
|---|
| GO ID | 0008233 |
|---|---|
| 0004252 | |
| 0007596 | |
| 0006464 | |
| 0006508 | |
| 0005856 | |
| 0005576 | |
| 0016787 | |
| 0008236 | |
| 0048008 | |
| 0001666 | |
| 0014909 | |
| 0045177 | |
| 0005737 | |
| 0005615 | |
| 0030141 | |
| 0048514 | |
| 0048167 | |
| 0035249 | |
| 0045202 |
| IPI ID | IPI00019590 |
|---|---|
| IPI00479511 | |
| IPI00180407 | |
| IPI00910450 | |
| IPI00295285 | |
| IPI00319513 | |
| IPI00332012 |
| Mouse chromosome position | 8 9.0 cM |
|---|
| Homologene ID | 717 |
|---|
| MGI ID | 97610 |
|---|
| Rat chromosome position | 16q12.5 |
|---|
| RGD ID | 3342 |
|---|