| URN | urn:agi-llid:5915 |
|---|---|
| Connectivity | 169 |
| Name | RARB |
| Description | retinoic acid receptor, beta |
| Notes | This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. The gene expresses at least two transcript variants; one additional transcript has been described, but its full length nature has not been determined. [provided by RefSeq] |
| Pathway | NR Table |
|---|---|
| NR Direct Interactions | |
| RARA Targets | |
| RARB Targets | |
| PPARG Targets | |
| LXRB Targets | |
| FXR Targets | |
| VDR Targets | |
| ERA Pathway | |
| ERB Targets | |
| TR3 Targets |
| Ariadne Ontology | Tumor suppressors |
|---|---|
| Thr-like |
| GO Molecular Function | metal ion binding |
|---|---|
| zinc ion binding | |
| DNA binding | |
| sequence-specific DNA binding | |
| transcription factor activity | |
| receptor activity | |
| ligand-dependent nuclear receptor activity | |
| steroid hormone receptor activity | |
| retinoic acid receptor activity | |
| transcription activator activity |
| GO Cellular Component | cellular_component |
|---|---|
| cytoplasm | |
| nucleus |
| GO Biological Process | negative regulation of cell proliferation |
|---|---|
| negative regulation of transcription from RNA polymerase II promoter | |
| positive regulation of programmed cell death | |
| positive regulation of apoptosis | |
| positive regulation of transcription from RNA polymerase II promoter | |
| signal transduction | |
| regulation of transcription, DNA-dependent | |
| ventricular cardiac muscle cell differentiation | |
| transcription | |
| ureteric bud development | |
| embryonic hindlimb morphogenesis | |
| embryonic eye morphogenesis |
| Group | Tumor suppressors |
|---|---|
| Thr-like | |
| cellular_component | |
| cytoplasm | |
| nucleus | |
| metal ion binding | |
| zinc ion binding | |
| DNA binding | |
| sequence-specific DNA binding | |
| transcription factor activity | |
| receptor activity | |
| ligand-dependent nuclear receptor activity | |
| steroid hormone receptor activity | |
| retinoic acid receptor activity | |
| transcription activator activity | |
| negative regulation of cell proliferation | |
| negative regulation of transcription from RNA polymerase II promoter | |
| positive regulation of programmed cell death | |
| positive regulation of apoptosis | |
| positive regulation of transcription from RNA polymerase II promoter | |
| signal transduction | |
| regulation of transcription, DNA-dependent | |
| ventricular cardiac muscle cell differentiation | |
| transcription | |
| ureteric bud development | |
| embryonic hindlimb morphogenesis | |
| embryonic eye morphogenesis |
| Hugo ID | 9865 |
|---|
| Human chromosome position | 3p24 |
|---|
| LocusLink ID | 5915 |
|---|---|
| 218772 |
| Alias | HAP |
|---|---|
| RRB2 | |
| NR1B2 | |
| retinoic acid receptor, beta | |
| RAR-epsilon | |
| HBV-activated protein | |
| retinoic acid receptor beta 2 | |
| retinoic acid receptor beta 4 | |
| retinoic acid receptor beta 5 | |
| hepatitis B virus activated protein | |
| retinoic acid receptor, beta polypeptide | |
| RARbeta2 | |
| A830025K23 | |
| RAR beta 2 | |
| RARbeta1/beta3 | |
| retinoic acid receptor beta 1/ beta 3 | |
| RAR beta | |
| RAR-beta-2 | |
| Retinoic acid receptor beta (RAR-beta) | |
| retinoic acid receptor beta IV | |
| retinoic acid receptor beta II | |
| RARB | |
| RAR-beta II | |
| RAR-eta | |
| retinoic acid receptor beta V | |
| retinoic acid receptor beta | |
| retinoic acid receptor-beta associated open reading frame | |
| LOC51036 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus |
| OMIM ID | 180220 |
|---|
| Swiss-Prot Accession | P10826 |
|---|---|
| Q5QHG3 | |
| Q15299 | |
| Q3SB16 | |
| Q6FHY0 | |
| Q86UC5 | |
| P22605 | |
| Q6DFX0 | |
| Q8K1P6 |
| Unigene ID | Hs.654490 |
|---|---|
| Mm.259318 |
| KEGG ID | hsa:5915 |
|---|---|
| mmu:218772 |
| Swiss-Prot ID | RARB_HUMAN |
|---|---|
| RARB_MOUSE | |
| Q5QHG3_HUMAN | |
| Q6DFX0_MOUSE |
| Cell Localization | Nucleus |
|---|
| GO ID | 0046872 |
|---|---|
| 0003708 | |
| 0043565 | |
| 0003707 | |
| 0016563 | |
| 0003700 | |
| 0008270 | |
| 0048048 | |
| 0035116 | |
| 0008285 | |
| 0000122 | |
| 0043065 | |
| 0045944 | |
| 0006355 | |
| 0007165 | |
| 0006350 | |
| 0001657 | |
| 0055012 | |
| 0005575 | |
| 0005737 | |
| 0005634 | |
| 0003677 | |
| 0004879 | |
| 0004872 | |
| 0043068 |
| IPI ID | IPI00022989 |
|---|---|
| IPI00745428 | |
| IPI00219014 | |
| IPI00026250 | |
| IPI00651730 | |
| IPI00219013 | |
| IPI00130386 | |
| IPI00230346 | |
| IPI00230347 | |
| IPI00230348 |
| Mouse chromosome position | 14 A1-A3 |
|---|
| Homologene ID | 68100 |
|---|
| MGI ID | 97857 |
|---|