Protein IL8RB

URN	urn:agi-llid:3579
Connectivity	256
Name	IL8RB
Description	interleukin 8 receptor, beta
Notes	The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq]

Pathway	IL8R -> CREB/EGR signaling
	PPARG Targets

Ariadne Ontology	GPCR-GqCR

GO Molecular Function	protein binding
	chemokine receptor activity
	interleukin-8 receptor activity
	signal transducer activity
	receptor activity
	G-protein coupled receptor activity

GO Biological Process	positive regulation of cell proliferation
	signal transduction
	G-protein coupled receptor protein signaling pathway
	activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger
	neutrophil activation
	apoptosis
	neutrophil chemotaxis
	chemotaxis
	inflammatory response
	cellular defense response

Group	GPCR-GqCR
	intracellular
	cell surface
	membrane
	mast cell granule
	plasma membrane
	integral to membrane
	integral to plasma membrane
	protein binding
	chemokine receptor activity
	interleukin-8 receptor activity
	signal transducer activity
	receptor activity
	G-protein coupled receptor activity
	positive regulation of cell proliferation
	signal transduction
	G-protein coupled receptor protein signaling pathway
	activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger
	neutrophil activation
	apoptosis
	neutrophil chemotaxis
	chemotaxis
	inflammatory response
	cellular defense response

Hugo ID	6027

Human chromosome position	2q35

Alias	CD182
	CXCR2
	IL8R2
	IL8RA
	CMKAR2
	CDw128b
	interleukin 8 receptor beta
	GRO/MGSA receptor
	interleukin 8 receptor B
	chemokine (CXC) receptor 2
	interleukin 8 receptor type 2
	interleukin-8 receptor type B
	CXCR2 gene for IL8 receptor type B
	chemokine (C-X-C motif) receptor 2
	high affinity interleukin-8 receptor B
	CD128
	CDw128
	Gpcr16
	IL-8Rh
	IL-8rb
	mIL-8RH
	IL-8 receptor alpha chain
	chemokine (C-X-C) receptor 2
	interleukin 8 receptor, beta
	CXC chemokine receptor 1-like
	LOC227288
	interleukin 8 receptor type II
	IL-8Rhs
	GRO/MGSA receptors
	IL-8 receptor type 2
	IL8RB
	IL8 R beta
	IL-8R B
	gene for IL8 receptor type B
	IL8B_HUMAN
	IL-8 receptor type II
	IL 8 Receptor beta
	chemokine (CXC) receptor II
	chemokine (C-X-C) receptor II
	CDw128s
	CMKAR2s
	Gpcr16s

OMIM ID	146928

Cell Localization	Plasma membrane

Mouse chromosome position	1 40.0 cM

Homologene ID	10439

MGI ID	105303

Rat chromosome position	9q33

RGD ID	2906