| URN | urn:agi-llid:5468 |
|---|---|
| Connectivity | 1459 |
| Name | PPARG |
| Description | peroxisome proliferator-activated receptor gamma |
| Notes | This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq] |
| Pathway | Common Regulators |
|---|---|
| NR Table | |
| NR Direct Interactions | |
| PPARA Targets | |
| PPARD Targets | |
| PPARG Targets | |
| NR1D1 Targets | |
| LXRA Targets | |
| FXR Targets | |
| NR2F2 Targets | |
| ERRA Targets | |
| PGR Targets | |
| SHP1 Targets | |
| Common Regulators and Small Molecules |
| Ariadne Ontology | Thr-like |
|---|
| GO Molecular Function | protein binding |
|---|---|
| drug binding | |
| metal ion binding | |
| zinc ion binding | |
| arachidonic acid binding | |
| DNA binding | |
| sequence-specific DNA binding | |
| transcription factor activity | |
| transcription activator binding | |
| protein heterodimerization activity | |
| retinoid X receptor binding | |
| receptor activity | |
| ligand-dependent nuclear receptor activity | |
| steroid hormone receptor activity | |
| prostaglandin receptor activity | |
| transcription activator activity | |
| transcription repressor activity |
| GO Cellular Component | cytosol |
|---|---|
| nucleus | |
| transcriptional repressor complex |
| GO Biological Process | negative regulation of cell proliferation |
|---|---|
| negative regulation of cell growth | |
| negative regulation of foam cell differentiation | |
| negative regulation of cellular protein metabolic process | |
| negative regulation of transcription, DNA-dependent | |
| negative regulation of transcription from RNA polymerase II promoter | |
| negative regulation of specific transcription from RNA polymerase II promoter | |
| negative regulation of lipid metabolic process | |
| negative regulation of cytokine production | |
| negative regulation of acute inflammatory response | |
| positive regulation of fat cell differentiation | |
| positive regulation of oligodendrocyte differentiation | |
| positive regulation of transcription | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of specific transcription from RNA polymerase II promoter | |
| positive regulation of fatty acid oxidation | |
| signal transduction | |
| regulation of fat cell differentiation | |
| regulation of transcription | |
| regulation of transcription, DNA-dependent | |
| regulation of transcription from RNA polymerase II promoter | |
| regulation of lipid metabolic process | |
| regulation of blood pressure | |
| lipid homeostasis | |
| glucose homeostasis | |
| negative regulation of telomerase activity | |
| cell fate commitment | |
| cell maturation | |
| fat cell differentiation | |
| epithelial cell differentiation | |
| brown fat cell differentiation | |
| white fat cell differentiation | |
| monocyte differentiation | |
| transcription | |
| fatty acid metabolic process | |
| fatty acid oxidation | |
| cellular response to insulin stimulus | |
| organ regeneration | |
| placenta development | |
| lipoprotein transport | |
| long-chain fatty acid transport | |
| innate immune response | |
| low-density lipoprotein receptor biosynthetic process | |
| response to cold | |
| response to drug | |
| response to organic substance | |
| response to nutrient | |
| response to estrogen stimulus | |
| response to vitamin A | |
| response to organic cyclic substance | |
| response to lipid | |
| response to caffeine | |
| response to low density lipoprotein stimulus | |
| inflammatory response |
| Group | Thr-like |
|---|---|
| cytosol | |
| nucleus | |
| transcriptional repressor complex | |
| protein binding | |
| drug binding | |
| metal ion binding | |
| zinc ion binding | |
| arachidonic acid binding | |
| DNA binding | |
| sequence-specific DNA binding | |
| transcription factor activity | |
| transcription activator binding | |
| protein heterodimerization activity | |
| retinoid X receptor binding | |
| receptor activity | |
| ligand-dependent nuclear receptor activity | |
| steroid hormone receptor activity | |
| prostaglandin receptor activity | |
| transcription activator activity | |
| transcription repressor activity | |
| negative regulation of cell proliferation | |
| negative regulation of cell growth | |
| negative regulation of foam cell differentiation | |
| negative regulation of cellular protein metabolic process | |
| negative regulation of transcription, DNA-dependent | |
| negative regulation of transcription from RNA polymerase II promoter | |
| negative regulation of specific transcription from RNA polymerase II promoter | |
| negative regulation of lipid metabolic process | |
| negative regulation of cytokine production | |
| negative regulation of acute inflammatory response | |
| positive regulation of fat cell differentiation | |
| positive regulation of oligodendrocyte differentiation | |
| positive regulation of transcription | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of specific transcription from RNA polymerase II promoter | |
| positive regulation of fatty acid oxidation | |
| signal transduction | |
| regulation of fat cell differentiation | |
| regulation of transcription | |
| regulation of transcription, DNA-dependent | |
| regulation of transcription from RNA polymerase II promoter | |
| regulation of lipid metabolic process | |
| regulation of blood pressure | |
| lipid homeostasis | |
| glucose homeostasis | |
| negative regulation of telomerase activity | |
| cell fate commitment | |
| cell maturation | |
| fat cell differentiation | |
| epithelial cell differentiation | |
| brown fat cell differentiation | |
| white fat cell differentiation | |
| monocyte differentiation | |
| transcription | |
| fatty acid metabolic process | |
| fatty acid oxidation | |
| cellular response to insulin stimulus | |
| organ regeneration | |
| placenta development | |
| lipoprotein transport | |
| long-chain fatty acid transport | |
| innate immune response | |
| low-density lipoprotein receptor biosynthetic process | |
| response to cold | |
| response to drug | |
| response to organic substance | |
| response to nutrient | |
| response to estrogen stimulus | |
| response to vitamin A | |
| response to organic cyclic substance | |
| response to lipid | |
| response to caffeine | |
| response to low density lipoprotein stimulus | |
| inflammatory response |
| Hugo ID | 9236 |
|---|
| Human chromosome position | 3p25 |
|---|
| LocusLink ID | 5468 |
|---|---|
| 19016 | |
| 25664 |
| Alias | CIMT1 |
|---|---|
| NR1C3 | |
| PPARG1 | |
| PPARG2 | |
| PPARgamma | |
| peroxisome proliferative activated receptor gamma | |
| PPAR gamma | |
| OTTHUMP00000185030 | |
| OTTHUMP00000185033 | |
| OTTHUMP00000185037 | |
| nuclear receptor subfamily 1 group C member 3 | |
| peroxisome proliferator-activated receptor gamma 1 | |
| PPAR-gamma | |
| PPARgamma2 | |
| PPAR-gamma2 | |
| peroxisome proliferator activated receptor gamma | |
| peroxisome proliferator activated receptor gamma 2 | |
| peroxisome proliferator-activated receptor gamma | |
| peroxisome proliferator activator receptor, gamma | |
| peroxisome proliferative activated receptor gamma isoform 1 | |
| PPARG I | |
| HUMPPARG | |
| peroxisome proliferative activated receptor gamma isoform 2 | |
| peroxisome proliferative activated receptor, gamma | |
| peroxisome proliferative activated receptor gamma isoform I | |
| peroxisome proliferative activated receptor gamma isoform II | |
| Pparg | |
| peroxisome proliferator activated receptor | |
| peroxisome proliferator activator receptor gamma | |
| PPAR gamma2 | |
| PPARG2s | |
| PPARG1s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601487 |
|---|---|
| 609338 | |
| 604367 | |
| 125853 | |
| 137800 | |
| 151660 | |
| 601665 |
| Swiss-Prot Accession | B5BUA1 |
|---|---|
| P37231 | |
| Q0QJH8 | |
| Q4W448 | |
| Q4W4C6 | |
| Q4W4C7 | |
| Q53EW1 | |
| Q6L9M1 | |
| Q86WD1 | |
| Q9UEF6 | |
| Q4FJR2 | |
| P37238 | |
| Q6GU14 | |
| Q6TQE4 | |
| O88275 |
| Unigene ID | Hs.162646 |
|---|---|
| Mm.3020 | |
| Rn.23443 |
| KEGG ID | hsa:5468 |
|---|---|
| rno:25664 |
| Swiss-Prot ID | PPARG_HUMAN |
|---|---|
| PPARG_MOUSE | |
| PPARG_RAT | |
| Q4FJR2_MOUSE | |
| Q6GU14_MOUSE |
| Cell Localization | Nucleus |
|---|
| GO ID | 0050544 |
|---|---|
| 0008144 | |
| 0046872 | |
| 0004955 | |
| 0046982 | |
| 0046965 | |
| 0043565 | |
| 0003707 | |
| 0016563 | |
| 0033613 | |
| 0003700 | |
| 0016564 | |
| 0008270 | |
| 0045165 | |
| 0048469 | |
| 0032869 | |
| 0030855 | |
| 0042593 | |
| 0045087 | |
| 0055088 | |
| 0042953 | |
| 0015909 | |
| 0045713 | |
| 0030224 | |
| 0032269 | |
| 0010745 | |
| 0045833 | |
| 0010553 | |
| 0001890 | |
| 0045600 | |
| 0010552 | |
| 0045941 | |
| 0008217 | |
| 0033993 | |
| 0055098 | |
| 0007584 | |
| 0007165 | |
| 0050872 | |
| 0005829 | |
| 0005634 | |
| 0003677 | |
| 0004879 | |
| 0005515 | |
| 0004872 | |
| 0050873 | |
| 0045444 | |
| 0006954 | |
| 0008285 | |
| 0001818 | |
| 0000122 | |
| 0045892 | |
| 0045944 | |
| 0045598 | |
| 0045449 | |
| 0006355 | |
| 0006350 | |
| 0017053 | |
| 0006631 | |
| 0019395 | |
| 0002674 | |
| 0030308 | |
| 0051974 | |
| 0031100 | |
| 0046321 | |
| 0048714 | |
| 0019216 | |
| 0006357 | |
| 0031000 | |
| 0009409 | |
| 0042493 | |
| 0043627 | |
| 0014070 | |
| 0010033 | |
| 0033189 |
| IPI ID | IPI00853091 |
|---|---|
| IPI00020897 | |
| IPI00913931 | |
| IPI00797909 | |
| IPI00852773 | |
| IPI00791321 | |
| IPI00853034 | |
| IPI00853274 | |
| IPI00125193 | |
| IPI00896034 | |
| IPI00266075 | |
| IPI00207539 | |
| IPI00231890 |
| Mouse chromosome position | 6 52.7 cM |
|---|
| Homologene ID | 7899 |
|---|
| MGI ID | 97747 |
|---|
| Rat chromosome position | 4q42 |
|---|
| RGD ID | 3371 |
|---|