| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:5465:out-urn:agi-llid:7350::positive |
|---|---|
| References | 7 |
| Connectivity | 2 |
| Effect | positive |
| Tissue | fat |
|---|---|
| TextRef | info:pmid/18195045#cont:438 |
| MedLine Reference | 18195045:10437 |
| Sentence | Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. |
| Journal | Mol. Cell. Biol |
| Journal Reference | v28 i7 p2187 |
| Journal Link | http://mcb.asm.org/cgi/content/full/28/7/2187 |
| Tissue | fat |
|---|---|
| TextRef | info:pmid/16227589#cont:236 |
| MedLine Reference | 16227589:10235 |
| Sentence | Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. |
| Journal | Mol. Cell. Biol |
| Journal Reference | v25 i21 p9383 |
| Journal Link | http://mcb.asm.org/cgi/content/full/25/21/9383 |
| Tissue | fat |
|---|---|
| TextRef | info:pmid/16135818#cont:324 |
| MedLine Reference | 16135818:10323 |
| Sentence | Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. |
| Journal | Mol. Cell. Biol |
| Journal Reference | v25 i18 p8311 |
| Journal Link | http://mcb.asm.org/cgi/content/full/25/18/8311 |
| TextRef | info:pmid/17726147#cont:216 |
|---|---|
| MedLine Reference | 17726147:10215 |
| Sentence | The UCP1 promoter contains a PPAR-responsive element (PPRE) that behaves as a promiscuous responsive site to either PPARa or PPAR? activation but not to PPARd ( 3 ). |
| Journal | Endocrin. Metabol |
| Journal Reference | v293 i5 p1159 |
| Journal Link | http://ajpendo.physiology.org/cgi/content/full/293/5/E1159 |
| CellType | adipocyte |
| TextRef | info:pmid/17456798#cont:78 |
|---|---|
| MedLine Reference | 17456798:10077 |
| Sentence | Therefore, because PPARa is a key activator of Ucp1 expression ( 29 ), the elevated basal levels of Ucp1 in the absence of RIP140 may result from the increased expression of this isoform. |
| Journal | Mol. Endocrin |
| Journal Reference | v21 i7 p1581 |
| Journal Link | http://mend.endojournals.org/cgi/content/full/21/7/1581 |
| CellType | adipocyte |
| TextRef | info:pmid/16840543#cont:144 |
|---|---|
| MedLine Reference | 16840543:10143 |
| Sentence | The UCP1 gene promoter contains a complex retinoic acid response element aside from a PPAR response element, and thus can also be regulated by ATRA through RAR activation, as demonstrated in brown adipocytes ( 30 , 31 ). |
| Journal | Endocrinology |
| Journal Reference | v147 i11 p5325 |
| Journal Link | http://endo.endojournals.org/cgi/content/full/147/11/5325 |
| CellType | adipocyte |
| CellLineName | WK |
|---|---|
| Organism | Mus musculus |
| Tissue | mammary gland |
| TextRef | info:pmid/12040007#cont:246 |
| MedLine Reference | 12040007:10245 |
| Sentence | Given that PGC-1 has been shown to act as a transcriptional coactivator for PPARa ( 52 , 48 ), and that high levels of PPARa mRNA are found in the 2-wk-old mammary gland, it is possible that basal levels of PGC-1 and PPARa expression are sufficient for high levels of expression of Ucp1 in the mammary glands of neonatal mice housed at room temperature. |
| Journal | Mol. Endocrin |
| Journal Reference | v16 i6 p1185 |
| Journal Link | http://mend.endojournals.org/cgi/content/full/16/6/1185 |