| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:5465:out-urn:agi-llid:34::positive |
|---|---|
| References | 9 |
| Connectivity | 2 |
| Effect | positive |
| TextRef | info:pmid/15654129#cont:232 |
|---|---|
| MedLine Reference | 15654129:10231 |
| Sentence | This was not observed for MCAD, VLCAD, and MTP, which have been reported to be regulated via PPARa ( 12 ). |
| Journal | Lipid Res |
| Journal Reference | v46 i4 p716 |
| Journal Link | http://www.jlr.org/cgi/content/full/46/4/716 |
| Tissue | muscle |
|---|---|
| TextRef | info:pmid/10529898#cont:543 |
| MedLine Reference | 10529898:10542 |
| Sentence | PPARa further regulates the mitochondrialß-oxidative spiral by modulating the expression of the medium-chainacyl-CoA dehydrogenase (MCAD) gene ( 236 ). |
| Journal | Endocrine Reviews |
| Journal Reference | v20 i5 p649 |
| Journal Link | http://edrv.endojournals.org/cgi/content/full/20/5/649 |
| Tissue | floral |
|---|---|
| TextRef | info:pmid/17550978#cont:204 |
| Organ | intestine |
| MedLine Reference | 17550978:10203 |
| Sentence | For example, because medium-chain acyl-CoA dehydrogenase is up-regulated by PPARa ( 21 ), hexanoyl-CoA would be expected to be ß-oxidized rapidly, with little conjugation to hexanoylglycine taking place. |
| Journal | Mol. Endocrin |
| Journal Reference | v21 i9 p2136 |
| Journal Link | http://mend.endojournals.org/cgi/content/full/21/9/2136 |
| TextRef | info:pmid/12920214#cont:208 |
|---|---|
| Organ | heart |
| MedLine Reference | 12920214:10207 |
| Sentence | Therefore, given the strong dependence of MCAD on PPARalpha levels, the presence of normal levels of PPARalpha in hearts of troglitazone-treated mice may be responsible for the unchanged MCAD expression. |
| Journal | Mol. Pharm |
| Journal Reference | v64 i3 p764 |
| Journal Link | http://molpharm.aspetjournals.org/cgi/content/full/64/3/764 |
| Organism | Rattus norvegicus |
|---|---|
| Tissue | fat |
| TextRef | info:pmid/9815135#cont:170 |
| Organ | gastric |
| MedLine Reference | 9815135:10169 |
| Sentence | In fact, cotransfection experiments indicate that, after activation by fatty acids, PPARalpha mediates transcriptional stimulation of MCAD, ACO, and other genes involved in fatty acid catabolism ( 27 ). |
| Journal | Renal Phys |
| Journal Reference | v275 i5 pF777 |
| Journal Link | http://ajprenal.physiology.org/cgi/content/full/275/5/F777 |
| Tissue | skeletal |
|---|---|
| TextRef | info:pmid/11574533#cont:68 |
| MedLine Reference | 11574533:10067 |
| Sentence | Expression of PPARalpha and PPARalpha-regulated Genes-- We investigated the effects of both pressure overload and chronic PPARalpha activation on the mRNA levels of PPARalpha and the PPARalpha-regulated genes, medium chain acyl-CoA dehydrogenase and pyruvate dehydrogenase kinase 4. |
| Journal | J. Biol. Chem |
| Journal Reference | v276 i48 p44390 |
| Journal Link | http://www.jbc.org/cgi/content/full/276/48/44390 |
| TextRef | info:pmid/15456881#cont:326 |
|---|---|
| Organ | heart |
| MedLine Reference | 15456881:10325 |
| Sentence | Indeed, our previous work demonstrated that ERRalpha with PGC-1alpha directly activates the MCAD gene promoter in transient transfection assays through NRRE-1, a pleiotropic nuclear receptor response element that has been shown to bind both PPARalpha and ERRalpha ( 14 , 19 , 43 , 47 ). |
| Journal | Mol. Cell. Biol |
| Journal Reference | v24 i20 p9079 |
| Journal Link | http://mcb.asm.org/cgi/content/full/24/20/9079 |
| CellType | myocyte |
| TextRef | info:pmid/10464303#cont:29 |
|---|---|
| Organ | heart |
| MedLine Reference | 10464303:10028 |
| Sentence | Studies performed in cell culture ( 24 , 25 ) and in vivo ( 26 , 27 ) have demonstrated that basal and fatty acid stimulated expression of the MCAD and muscle carnitine palmitoyltransferase I genes in heart and liver is controlled in part by RXRalpha/PPARalpha heterodimers. |
| Journal | J. Biol. Chem |
| Journal Reference | v274 i36 p25668 |
| Journal Link | http://www.jbc.org/cgi/content/full/274/36/25668 |
| TextRef | info:pmid/15226431#cont:121 |
|---|---|
| MedLine Reference | 15226431:10120 |
| Sentence | Since fatty acid metabolism has been studied to a great extent in peroxisome proliferation, 7 of the 12 proteins, AOX ( 4 , 25 , 44 , 51 ), medium-chain acyl-CoA dehydrogenase ( 7 , 34 ), acyl-CoA thioesterase 1 ( 9 , 47 , 48 ), 3-hydroxy-3-methylglutaryl-CoA synthase 1 ( 45 ), 3-ketoacyl-CoA thiolase A ( 33 , 44 ), acyl-CoA thioester hydrolase ( 2 ), and L -peroxisomal bifunctional enzyme ( 33 , 37 , 44 ), had previously been reported to be regulated in AOX?/? mice or regulated by peroxisome proliferator treatment due to PPARalpha activation. |
| Journal | Mol. Cell. Biol |
| Journal Reference | v24 i14 p6288 |
| Journal Link | http://mcb.asm.org/cgi/content/full/24/14/6288 |