| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:5465:out-urn:agi-llid:51::positive |
|---|---|
| References | 8 |
| Connectivity | 2 |
| Effect | positive |
| Organism | Rattus norvegicus |
|---|---|
| TextRef | info:pmid/10839475#abs:8 |
| MedLine Reference | 10839475:7 |
| Sentence | PPs activate the peroxisome proliferator activated receptor alpha (PPARalpha) that binds to DNA at peroxisome proliferator response elements (PPREs) within the promoters of PP-responsive genes such as rat acyl CoA oxidase (ACO). |
| CellType | hepatocyte |
| TextRef | info:pmid/17510198#cont:195 |
|---|---|
| Organ | liver |
| MedLine Reference | 17510198:10194 |
| Sentence | hepatic PPAR binding to the PPRE in the ACO promoter. |
| Journal | Gastr. Liver Phys |
| Journal Reference | v293 i1 p355 |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/293/1/G355 |
| TextRef | info:pmid/17947452#cont:214 |
|---|---|
| Organ | liver |
| MedLine Reference | 17947452:10213 |
| Sentence | representative EMSA showing the effect of rats fed 5 or 70% corn oil, 220 kcal.kg -3/4 .day -1 on hepatic PPARa binding to the PPRE in the ACO promoter. |
| Journal | Gastr. Liver Phys |
| Journal Reference | v294 i1 p27 |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/294/1/G27 |
| TextRef | info:pmid/11117527#cont:9 |
|---|---|
| Organ | liver |
| MedLine Reference | 11117527:10008 |
| Sentence | Moreover, comparing PPARa knockout (KO) with PPARa WT mice, we show that the expression of the acyl CoA oxidase (ACO) gene can be regulated by PKA-activated PPARa in liver. |
| Journal | Mol. Endocrin |
| Journal Reference | v14 i12 p1962 |
| Journal Link | http://mend.endojournals.org/cgi/content/full/14/12/1962 |
| Tissue | serum |
|---|---|
| TextRef | info:pmid/12514267#cont:215 |
| MedLine Reference | 12514267:10214 |
| Sentence | The role of fibrates as inducers of peroxisomal fatty acid ß-oxidation is well established and is mediated by PPARalpha-induced expression of ACOX in the peroxisome (53 ). |
| Journal | Nutrition |
| Journal Reference | v133 i1 p57 |
| Journal Link | http://www.nutrition.org/cgi/content/full/133/1/57 |
| TextRef | info:pmid/11027271#cont:23 |
|---|---|
| MedLine Reference | 11027271:10022 |
| Sentence | The first natural PPAR-responsive element (PPRE) was identified in the promoter of the acyl coenzyme A (acyl-CoA) oxidase gene ( 13 , 48 ), and the analyses of all identified PPREs have revealed a consensus sequence, 5'-AACT AGGNCA A AGGTCA -3' ( 39 ). |
| Journal | Mol. Cell. Biol |
| Journal Reference | v20 i21 p8008 |
| Journal Link | http://mcb.asm.org/cgi/content/full/20/21/8008 |
| CellType | fibroblast |
| Tissue | serum |
|---|---|
| TextRef | info:pmid/10862787#cont:65 |
| MedLine Reference | 10862787:10064 |
| Sentence | The M-CPT I promoter?luciferase gene reporter plasmids MCPT.Luc.781 and MCPT.Luc.781m1, and the TK promoter?luciferase reporter plasmid (FARE-1) 2 TKLuc have been described ( 9 ). (ACO) 3 TKLuc was generated by cloning tandem copies of the PPARa response element identified in the rat acyl-CoA oxidase promoter ( 21 ) into the Bam HI site of the TKLuc backbone vector. (UAS) 3 TKLuc and the PPARa expression plasmid (pCDM.PPAR) have been described ( 6 , 22 ). |
| Journal | J Clin Invest |
| Journal Reference | v105 i12 p1723 |
| Journal Link | http://www.jci.org/cgi/content/full/105/12/1723 |
| CellLineName | THP I |
|---|---|
| MedLine Reference | 168100661:10035 |
| Sentence | Analysis of this 933 bp region revealed a DR-1 element, the preferred binding site for PPARheterodimers, between assays verified that only PPARDR-1 PPAR response element (PPRE) of the LXRsubtypes of PPARs bound the PPRE from the acyl-CoA oxidase (AOx) promoter ( Figure 2B ). |
| Journal | Molecular Cell |
| Journal Reference | v7 i1 p15 |
| Journal Link | http://www.molecule.org/content/article/fulltext?uid=PIIS1097276501001642 |
| CellType | macrophage |