| References | 3 |
|---|---|
| Connectivity | 2 |
| Effect | negative |
| URN | urn:agi-Expression:inout-urn:agi-llid:5467:out-urn:agi-llid:7124::negative |
| TextRef | info:pmid/16698033#abs:6 |
|---|---|
| MedLine Reference | 16698033:5 |
| Sentence | Our studies indicate that a PPARdelta-selective ligand inhibited lipopolysaccharide (LPS)-induced TNFalpha production from cardiomyocytes. |
| CellType | cardiomyocyte |
| TextRef | info:pmid/18337509#cont:116 |
|---|---|
| MedLine Reference | 18337509:10115 |
| Sentence | TIMP-3 can also inhibit TNFa-converting enzyme (TACE), resulting in reduced TNF shedding, indicating that PPARd may suppress TNFa signaling posttranslationally ( 50 ). |
| CellType | macrophage |
| Journal | PNAS |
| Journal Reference | v105 i11 p4271 |
| Journal Link | http://www.pnas.org/content/105/11/4271.full |
| TextRef | info:pmid/17488971#cont:188 |
|---|---|
| MedLine Reference | 17488971:10187 |
| Sentence | The ability of PPARd to display constitutive proinflammatory activity is evident from the observation that IL-1ß and MCP-1 expression in the presence of TNFa alone was greatly reduced in the absence of PPARd (Fig. 6B ). |
| CellLineName | THP I |
| Journal | Mol. Endocrin |
| Journal Reference | v21 i8 p1756 |
| Journal Link | http://mend.endojournals.org/cgi/content/full/21/8/1756 |