| References | 6 |
|---|---|
| Connectivity | 2 |
| Effect | positive |
| URN | urn:agi-Expression:inout-urn:agi-llid:5467:out-urn:agi-llid:7352::positive |
| Tissue | skeletal muscle |
|---|---|
| MedLine Reference | 16857752:10035 |
| Sentence | Studies on the transcriptional control of the human UCP3 gene established that both PPARa and PPARd can activate UCP3 gene transcription and mediate fatty acid effects through a PPAR-responsive element in the proximal region of the promoter ( 9 ). |
| Journal | Endocrinology |
| Journal Reference | v147 i10 p4695 |
| Journal Link | http://endo.endojournals.org/cgi/content/full/147/10/4695 |
| Tissue | skeletal muscle |
|---|---|
| MedLine Reference | 11564673:10009 |
| Sentence | Therefore, we conclude that UCP3 gene expression is increased by the activation of PPARdelta in L6 myotubes and postulate that PPARdelta mediates at least some part of the increased UCP3 gene expression by fatty acids in skeletal muscle in vivo . |
| CellType | myotube |
| CellLineName | L6 |
| Journal | Endocrinology |
| Journal Reference | v142 i10 p4189 |
| Journal Link | http://endo.endojournals.org/cgi/content/full/142/10/4189 |
| Tissue | skeletal muscle |
|---|---|
| MedLine Reference | 16278250:10074 |
| Journal | Endocrin. Metabol |
| Journal Reference | v290 i4 p607 |
| Journal Link | http://ajpendo.physiology.org/cgi/content/full/290/4/E607 |
| MedLine Reference | 12843208:10051 |
|---|---|
| Journal | Mol. Endocrin |
| Journal Reference | v17 i10 p1944 |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/10/1944 |
| MedLine Reference | 12118038:10214 |
|---|---|
| CellType | myotube |
| CellLineName | L6 |
| Journal | J. Biol. Chem |
| Journal Reference | v277 i29 p26089 |
| Journal Link | http://www.jbc.org/cgi/content/full/277/29/26089 |
| MedLine Reference | 16825600:10288 |
|---|---|
| CellType | cardiomyocyte |
| Journal | Cell Phys |
| Journal Reference | v291 i2 p203 |
| Journal Link | http://ajpcell.physiology.org/cgi/content/full/291/2/C203 |