| URN | urn:agi-llid:6696 |
|---|---|
| Connectivity | 1039 |
| Name | SPP1 |
| Description | secreted phosphoprotein 1 |
| Notes | sialoprotein that binds osteosarcoma cells; may play a role in osteoclast cell function [RGD] |
| Pathway | TRA Targets |
|---|---|
| PPARA Targets | |
| PPARG Targets | |
| LXRA Targets | |
| LXRB Targets | |
| VDR Targets | |
| NURR1 Targets | |
| ERA Pathway | |
| ERB Targets | |
| ERRA Targets | |
| ERRB Targets | |
| ERRG Pathway | |
| GR Targets | |
| MR Target Genes | |
| PGR Targets | |
| TR3 Targets | |
| NR4A3 Targets |
| Ariadne Ontology | ITGL |
|---|
| GO Molecular Function | protein binding |
|---|---|
| extracellular matrix binding | |
| cytokine activity |
| GO Cellular Component | extracellular region |
|---|---|
| cell projection | |
| apical part of cell | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| extracellular space | |
| membrane-bounded vesicle |
| GO Biological Process | cell adhesion |
|---|---|
| positive regulation of cell-substrate adhesion | |
| anti-apoptosis | |
| negative regulation of collateral sprouting of intact axon in response to injury | |
| positive regulation of bone resorption | |
| cell differentiation | |
| osteoblast differentiation | |
| ossification | |
| response to organic substance | |
| response to steroid hormone stimulus | |
| inflammatory response |
| Group | ITGL |
|---|---|
| extracellular region | |
| cell projection | |
| apical part of cell | |
| cytoplasm | |
| perinuclear region of cytoplasm | |
| extracellular space | |
| membrane-bounded vesicle | |
| protein binding | |
| extracellular matrix binding | |
| cytokine activity | |
| cell adhesion | |
| positive regulation of cell-substrate adhesion | |
| anti-apoptosis | |
| negative regulation of collateral sprouting of intact axon in response to injury | |
| positive regulation of bone resorption | |
| cell differentiation | |
| osteoblast differentiation | |
| ossification | |
| response to organic substance | |
| response to steroid hormone stimulus | |
| inflammatory response |
| Hugo ID | 11255 |
|---|
| Human chromosome position | 4q21-q25 |
|---|
| LocusLink ID | 6696 |
|---|---|
| 20750 | |
| 25353 |
| Alias | OPN |
|---|---|
| BNSP | |
| BSPI | |
| ETA-1 | |
| MGC110940 | |
| secreted phosphoprotein 1 | |
| osteopontin | |
| SPP1/CALPHA1 fusion | |
| bone sialoprotein I | |
| early T-lymphocyte activation 1 | |
| secreted phosphoprotein-1 (osteopontin, bone sialoprotein) | |
| osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein | |
| secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1) | |
| OP | |
| Bsp | |
| Eta | |
| Ric | |
| Opnl | |
| Apl-1 | |
| Spp-1 | |
| AA960535 | |
| AI790405 | |
| minopontin | |
| OTTMUSP00000029095 | |
| OTTMUSP00000029097 | |
| OTTMUSP00000029098 | |
| bone sialoprotein 1 | |
| osteopontin-like protein | |
| 44kDa bone phosphoprotein | |
| 44 kDa bone phosphoprotein | |
| OSP | |
| Sialoprotein (osteopontin) | |
| early T-lymphocyte activating I | |
| early T-lymphocyte activating 1 | |
| Nephropontin | |
| Spp1 | |
| Uropontin | |
| early T-lymphocyte activation I | |
| Secreted phosphoprotein I | |
| Apl I | |
| Urinary stone protein | |
| Spp I | |
| ETA-I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 166490 |
|---|
| Swiss-Prot Accession | B2RDA1 |
|---|---|
| P10451 | |
| Q4W597 | |
| Q567T5 | |
| Q3LGB0 | |
| P10923 | |
| Q547B5 | |
| Q3TLP1 | |
| Q3TND2 | |
| Q3UBR1 | |
| Q3UZY3 | |
| Q6PKE3 | |
| P08721 | |
| P97827 |
| Unigene ID | Hs.313 |
|---|---|
| Mm.288474 | |
| Rn.8871 |
| KEGG ID | hsa:6696 |
|---|---|
| mmu:20750 | |
| rno:25353 |
| Swiss-Prot ID | OSTP_HUMAN |
|---|---|
| OSTP_MOUSE | |
| OSTP_RAT | |
| B2RDA1_HUMAN | |
| Q4W597_HUMAN | |
| Q567T5_HUMAN | |
| Q547B5_MOUSE |
| Cell Localization | Extracellular |
|---|
| GO ID | 0005125 |
|---|---|
| 0005515 | |
| 0007155 | |
| 0001503 | |
| 0005576 | |
| 0005615 | |
| 0050840 | |
| 0006916 | |
| 0010811 | |
| 0045177 | |
| 0005737 | |
| 0030154 | |
| 0006954 | |
| 0048685 | |
| 0001649 | |
| 0045780 | |
| 0010033 | |
| 0048545 | |
| 0042995 | |
| 0031988 | |
| 0048471 |
| IPI ID | IPI00021000 |
|---|---|
| IPI00218874 | |
| IPI00218875 | |
| IPI00385896 | |
| IPI00306339 | |
| IPI00309133 | |
| IPI00625970 | |
| IPI00857791 | |
| IPI00857936 | |
| IPI00856454 | |
| IPI00327895 |
| Mouse chromosome position | 5 56.0 cM |
|---|
| Homologene ID | 20156 |
|---|
| MGI ID | 98389 |
|---|
| Rat chromosome position | 14p22 |
|---|
| RGD ID | 3752 |
|---|