Protein TNFSF11

URN	urn:agi-llid:8600
Name	TNFSF11
Description	tumor necrosis factor (ligand) superfamily, member 11
Connectivity	589
Notes	This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.

Cell Localization	Extracellular

Pathway	Cardiovascular Disease (Large)
	VDR Targets

Ariadne Ontology	TNF family

Mouse chromosome position	14 45.0 cM

GO Molecular Function	protein binding
	cytokine activity
	tumor necrosis factor receptor binding
	receptor activity

Homologene ID	2744

Hugo ID	11926

MGI ID	1100089

Human chromosome position	13q14

GO Biological Process	protein homooligomerization
	positive regulation of osteoclast differentiation
	positive regulation of bone resorption
	regulation of osteoclast differentiation
	bone resorption
	cell differentiation
	osteoclast differentiation
	multicellular organismal development
	ossification
	organ morphogenesis
	lymph node development
	immune response
	response to stress
	response to radiation

Rat chromosome position	15q11

Group	TNF family
	extracellular region
	membrane
	cytoplasm
	plasma membrane
	integral to membrane
	integral to plasma membrane
	extracellular space
	protein binding
	cytokine activity
	tumor necrosis factor receptor binding
	receptor activity
	protein homooligomerization
	positive regulation of osteoclast differentiation
	positive regulation of bone resorption
	regulation of osteoclast differentiation
	bone resorption
	cell differentiation
	osteoclast differentiation
	multicellular organismal development
	ossification
	organ morphogenesis
	lymph node development
	immune response
	response to stress
	response to radiation

RGD ID	620784

Alias	ODF
	OPGL
	sOdf
	CD254
	OPTB2
	RANKL
	TRANCE
	hRANKL2
	tumor necrosis factor ligand superfamily, member 11
	OTTHUMP00000178585
	osteoprotegerin ligand
	osteoclast differentiation factor
	TNF-related activation-induced cytokine
	receptor activator of nuclear factor kappa B ligand
	OPG
	Ly109l
	tumor necrosis factor (ligand) superfamily, member 11
	OPG ligand
	receptor activator of NF-kappaB ligand
	tumor necrosis factor-related activation-induced cytokine
	Osteoclast differentiating factor
	osteoclast differentionation factor
	TNF-related activation- induced cytokine
	Tnfsf11
	tumor necrosis factor ligand superfamily, member 11 isoform 1
	tumor necrosis factor ligand superfamily, member 11 isoform I
	tumor necrosis factor ligand superfamily, member 11 isoform 2
	tumor necrosis factor ligand superfamily, member 11 isoform II

OMIM ID	602642
	259710