| URN | urn:agi-llid:3001 |
|---|---|
| Name | GZMA |
| Description | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) |
| Connectivity | 109 |
| Notes | Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. [provided by RefSeq] |
| Swiss-Prot Accession | P12544 |
|---|---|
| P11032 | |
| Q3U0N0 | |
| Q3UK79 | |
| Q8CJF4 |
| Unigene ID | Hs.90708 |
|---|---|
| Mm.15510 | |
| Rn.22283 |
| KEGG ID | hsa:3001 |
|---|---|
| mmu:14938 | |
| rno:266708 |
| EC Number | 3.4.21.78 |
|---|
| Swiss-Prot ID | GRAA_HUMAN |
|---|---|
| GRAA_MOUSE | |
| Q3U0N0_MOUSE | |
| Q8CJF4_RAT |
| GO ID | 0008233 |
|---|---|
| 0042803 | |
| 0004252 | |
| 0006915 | |
| 0006922 | |
| 0019835 | |
| 0006955 | |
| 0006508 | |
| 0005576 | |
| 0001772 | |
| 0005634 | |
| 0016787 | |
| 0008236 | |
| 0005515 |
| Pathway | VDR Targets |
|---|
| IPI ID | IPI00024657 |
|---|---|
| IPI00111385 | |
| IPI00229002 | |
| IPI00194804 |
| Mouse chromosome position | 13 64.0 cM |
|---|
| GO Molecular Function | protein binding |
|---|---|
| protein homodimerization activity | |
| hydrolase activity | |
| peptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity |
| Homologene ID | 21237 |
|---|
| Hugo ID | 4708 |
|---|
| GO Cellular Component | extracellular region |
|---|---|
| nucleus | |
| immunological synapse |
| MGI ID | 109266 |
|---|
| Human chromosome position | 5q11-q12 |
|---|
| GO Biological Process | cytolysis |
|---|---|
| apoptosis | |
| cleavage of lamin | |
| immune response | |
| proteolysis |
| Rat chromosome position | 2q14 |
|---|
| Group | extracellular region |
|---|---|
| nucleus | |
| immunological synapse | |
| protein binding | |
| protein homodimerization activity | |
| hydrolase activity | |
| peptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity | |
| cytolysis | |
| apoptosis | |
| cleavage of lamin | |
| immune response | |
| proteolysis |
| RGD ID | 628640 |
|---|
| LocusLink ID | 3001 |
|---|---|
| 14938 | |
| 266708 |
| Alias | HFSP |
|---|---|
| CTLA3 | |
| granzyme A | |
| CTL tryptase | |
| Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factor serine protease) | |
| Hf | |
| SE1 | |
| TSP1 | |
| TSP-1 | |
| Ctla-3 | |
| AW494114 | |
| H factor | |
| BLT esterase | |
| Hanukah factor | |
| serine esterase 1 | |
| Cytotoxic T-lymphocyte-associated serine esterase-3 | |
| Fragmentin 1 | |
| Granzyme 1 | |
| Hanukah factor serine protease | |
| Hanukkah factor | |
| HuTPS | |
| T-cell associated protease 1 | |
| cytotoxic T lymphocyte serine protease | |
| T-cell associated protease I | |
| Fragmentin I | |
| Granzyme I | |
| Cytotoxic T-lymphocyte proteinase 1 | |
| cytotoxic T lymphocyte serine proteases | |
| T-cell derived serine proteinases | |
| CTL tryptase | |
| Gzma | |
| T-cell derived serine proteinase | |
| Cytotoxic T-lymphocyte-associated serine esterase III | |
| Cytotoxic T-lymphocyte proteinase I | |
| granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 140050 |
|---|