Ariadne Genomics Inc. FXR PLAU TIMP2 NOS3 IL6 TNF GF PTGS2 EDN1 FAS Cytokine TNF family MMP9 metalloprotease TIMP1 TGF family KNG1 ICAM1 HDL fibroblast growth factor SERPINE1 fibrinogen NOS2A CEBPA CYP2B6 Jun/Fos ACTG2 ADIPOQ RARB NADPH oxidase retinoid-X receptor MMP2 HSPB1 CTGF BCL2A1 SREBF1 AGTR2 PPARG CRP death receptor PPARD SCD DCN ABCA1 MDR PTPN6 FABP PPARA SDC1 LRP2 PXR APOC1 apolipoprotein SCARB1 APOE APOC3 CYP3A4 PLTP CYP7A1 ABCB4 APOA1 CETP APOC2 LDLR DDAH1 SLC22A1 NR0B2 LIPC SLC2A4 CYP27A1 SLC10A2 VIPR1 VLDLR ABCB1 MTTP ABCG1 pyruvate kinase ABCG8 ABCG5 APOA5 CYP2C9 HNF4A orphan nuclear hormone receptor PCSK9 CYP19A1 NR5A2 cholesterol transporter acetyl CoA ligase bile acid transporter 20alpha-hydroxysteroid dehydrogenase ALAS1 MLXIPL RXRA HSD3B2 FETUB CYP51A1 ABCC4 ACACA COL1A1 FGF19 PCK2 PRMT1 TAS2R13 ABCC2 UPP1 FABP6 AKR1C2 PDK4 SLC1A5 carnitine O-palmitoyltransferase BAAT SLCO1B3 SULT2A1 CYP8B1 ABCB11 SLC10A1 THRSP CRYAA UGT2B4 PAPSS2 Ostbeta Ostalpha SLC27A5 FXR --+> ABCG8 FXR ---> Jun/Fos FXR --+> ABCG5 FXR ---> PXR FXR ---| CYP7A1 FXR ---| NOS2A FXR ---| CYP19A1 FXR ---> metalloprotease FXR ---| PTGS2 FXR ---| TIMP1 FXR --+> SDC1 FXR --+> FGF19 FXR ---> bile acid transporter FXR --+> NR5A2 FXR ---> SLCO1B3 FXR ---| MMP9 FXR ---| CYP3A4 FXR ---| TIMP2 FXR ---| APOC3 FXR ---> GF FXR --+> PPARA FXR ---| TNF FXR ---> Cytokine FXR ---| SREBF1 FXR --+> SCARB1 FXR ---> MMP2 FXR ---| CYP8B1 FXR --+> UGT2B4 FXR ---> CTGF FXR ---> IL6 FXR ---> SERPINE1 FXR ---> TGF family FXR ---| MLXIPL FXR ---| NADPH oxidase FXR ---| HDL FXR ---> TAS2R13 FXR ---> PAPSS2 FXR ---| CYP27A1 FXR --+> VLDLR FXR --+> orphan nuclear hormone receptor FXR --+> PPARG FXR --+> PCK2 FXR ---| SLC10A1 FXR --+> APOC2 FXR ---> apolipoprotein FXR --+> ABCC4 FXR --+> MDR FXR --+> NOS3 FXR ---| SCD FXR ---> SLC10A2 FXR ---| LIPC FXR ---| HNF4A FXR ---> LDLR FXR --+> acetyl CoA ligase FXR ---> APOE FXR ---| TNF family FXR --+> death receptor FXR ---> ABCA1 FXR ---| THRSP FXR ---> MTTP FXR ---> APOC1 FXR ---| ACACA FXR --+> ABCG1 FXR ---| pyruvate kinase FXR --+> SLC27A5 FXR --+> fibrinogen FXR ---> PPARD FXR ---| SLC22A1 FXR --+> PLAU FXR --+> ABCB1 FXR --+> BCL2A1 FXR ---| COL1A1 FXR ---| ACTG2 FXR ---> LRP2 FXR --+> DCN FXR --+> CRYAA FXR --+> SLC2A4 FXR --+> FETUB FXR ---| PCSK9 FXR ---> PDK4 FXR --+> fibroblast growth factor FXR --+> DDAH1 FXR --+> VIPR1 FXR ---| CRP FXR ---> cholesterol transporter FXR --+> AGTR2 FXR --+> HSD3B2 FXR --+> ALAS1 FXR ---| CETP FXR --+> CEBPA FXR ---> 20alpha-hydroxysteroid dehydrogenase FXR ---| UPP1 FXR ---| CYP2C9 FXR --+> FABP FXR --+> PRMT1 FXR ---> carnitine O-palmitoyltransferase FXR ---| CYP2B6 FXR ---| CYP51A1 FXR ---> ADIPOQ FXR ---| EDN1 FXR --+> PLTP FXR --+> ABCB11 FXR --+> ABCC2 FXR --+> ABCB4 FXR --+> FABP6 FXR --+> NR0B2 FXR ---> retinoid-X receptor FXR --+> PTPN6 FXR ---| SULT2A1 FXR ---> RXRA FXR ---| APOA1 FXR --+> AKR1C2 FXR --+> Ostbeta FXR --+> ICAM1 FXR --+> Ostalpha FXR --+> APOA5 FXR --+> KNG1 FXR --+> BAAT FXR ---> HSPB1 FXR --+> FAS FXR ---> RARB FXR ---> SLC1A5