Progesterone Receptor (PGR; NR3C3)

This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap.

[provided by RefSeq, Jan 2011]

Progesterone Receptor Structure

progesterone-receptor

(From Structure)

Link

(From Aceview)

There are 352 articles specifically referring to this gene in PubMed. Functionally, the gene has been tested for association to diseases (Abortion, Habitual; Adenocarcinoma; Aortic Aneurysm, Abdominal; Breast Neoplasms; Ductus Arteriosus, Patent; Endometriosis; Fibroadenoma; Genetic Predisposition to Disease; Hyperprolactinemia; Infant, Premature, Diseases and 7 others), proposed to participate in pathways (Oocyte meiosis, Progesterone-mediated oocyte maturation) and processes (epithelial cell maturation, mammary gland development, negative regulation of transcription, DNA-dependent, ovulation from ovarian follicle, positive regulation of transcription, DNA-dependent, progesterone receptor signaling pathway, regulation of epithelial cell proliferation, tertiary branching involved in mammary gland duct morphogenesis). Proteins are expected to have molecular functions (hormone binding, metal ion binding, sequence-specific DNA binding, steroid binding and 4 others) and to localize in various compartments (cytoplasm, nucleus, neuron projection). Putative protein interactors have been described (AMPD1ANDDENND2CANDBCAS2, ANKRD35ANDPIAS3, APEX2, BATF3, CCNA2, CDC25B, CSNK2A1, CUEDC2, DAP3, DDX54 and 33 others). 

(From HuGENavigator)

Over 70 Diseases associated with this receptor. Please see HuGENavigator for more information.

  • Breast Neoplasms 
  • Ovarian Neoplasms 
  • Endometriosis 
  • Premature Birth 
  • Endometrial Neoplasms 
  • Abortion, Habitual 
  • Colorectal Neoplasms 
  • Infertility, Female 
  • Leiomyoma 
  • Uterine Neoplasms 
  • Prostatic Neoplasms 
  • Migraine Disorders 
  • Inflammation 
  • Uterine Diseases 
  • Adenocarcinoma 
  • Carcinoma, Ductal, Breast 
  • Carcinoma, Lobular 
  • Cardiovascular Diseases 
  • Lung Neoplasms 
  • Infertility, Male 
  • Gallstones 
  • Stomach Neoplasms 
  • Tobacco Use Disorder 
  • Musculoskeletal Diseases 
  • Neoplasms 
  • Polycystic Ovary Syndrome 
  • Obesity 
  • Osteoporosis 
  • Ovarian Cysts 
  • Ovarian Failure, Premature 
  • Pregnancy Complications, Hematologic 
  • Panic Disorder 
  • Peritoneal Diseases 
  • Neoplasms, Cystic, Mucinous, and Serous 
  • Neoplasms, Glandular and Epithelial 
  • Neoplasms, Hormone-Dependent 
  • Neoplasm Invasiveness 
  • Kidney Failure, Chronic 
  • Urinary Bladder Neoplasms 
  • Thrombophilia 
  • Thyroid Neoplasms 
  • Vertigo 
  • Proteinuria 
  • Psychiatric Status Rating Scales 
  • Puberty, Delayed 
  • Puberty, Precocious 
  • Pulmonary Disease, Chronic Obstructive 
  • Skin Diseases 

Assay Kits and Services are available from INDIGO Biosciences.

Kits are offered in different assay formats to accommodate researchers’ needs: 3x 32, 1x 96, and 1x 384 assay formats for screening small numbers of test compounds, as well as custom bulk reagents for HTS applications. Assay systems are all inclusive, providing reporter cells, optimized growth media, media for diluting test compounds, a positive-control agonist, luciferase detection reagent, a white assay plate, a detailed protocol, and a protocol quick guide. All kits are shipped on dry ice.

PGR Reporter Cells are prepared using INDIGO’s proprietary CryoMite™ process. This cryo-preservation method yields high cell viability post-thaw, and provides the convenience of immediately dispensing healthy, division-competent reporter cells into assay plates. There is no need for intermediate spin-and-wash steps, viability determinations, or cell titer adjustments.

The principle application of this assay product is in the screening of test samples to quantify functional activities, either agonist or antagonist, that they may exert against the human progesterone receptor. This kit product is an all-inclusive assay system that includes, in addition to PGR Reporter Cells, two optimized media for use during cell culture and (optionally) in diluting the test samples, a reference agonist, Luciferase Detection Reagent, a cell culture-ready assay plate, and a detailed protocol.

MR; MCR; MLR; NR3C2VIT

(From Aceview)

The gene contains 14 distinct gt-ag introns. Transcription produces 11 different mRNAs, 10 alternatively spliced variants and 1 unspliced form. There are 4 probable alternative promotors, 2 non overlapping alternative last exons and 3 validated alternative polyadenylation sites (see the diagram). The mRNAs appear to differ by truncation of the 5′ end, presence or absence of 5 cassette exons, overlapping exons with different boundaries. 2141 bp of this gene are antisense to spliced geneklerflobu, raising the possibility of regulated alternate expression. 3 variants were isolated in vivo, despite the fact that they are predicted targets of nonsense mediated mRNA decay (NMD). 

Gene PGR

(From STRINGS)

AMPD1ANDDENND2CANDBCAS2, ANKRD35ANDPIAS3, APEX2, BATF3, CCNA2, CDC25B, CSNK2A1, CUEDC2, DAP3, DDX54 and 33 others

(From KEGG)

  • Norethisterone
  • Lynestrenol
  • Levonorgestrel
  • Quingestanol
  • Megestrol
  • Medroxyprogesterone
  • Norgestrienone
  • Etonogestrel
  • Desogestrel
  • Ulipristal
  • Gestonorone
  • Hydroxyprogesterone
  • Progesterone
  • Dydrogesterone
  • Medrogestone
  • Nomegestrol
  • Demegestone
  • Chlormadinone
  • Promegestone
  • Dienogest
  • Allylestrenol
  • Etynodiol
  • Danazol
  • Mifepristone

(From BioGPS)

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