Retinoid X Receptor Beta (RXRb; NR2B2)

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

[provided by RefSeq, Jul 2012]

NRR Pathway

rxr-heterodimers

Retinoid X Receptor Beta Structure

human-retinoid-x-receptor-beta

(From Structure)

Link

(From Aceview)

There are 56 articles specifically referring to this gene in PubMed. Functionally, the gene has been tested for association to diseases (Adenocarcinoma; Alcoholism; Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Bipolar Disorder; Carcinoma, Non-Small-Cell Lung; Cholesterol, HDL/blood*; Genetic Predisposition to Disease; Lung Neoplasms; Mental Disorders; Schizophrenia), proposed to participate in pathways (Adipocytokine signaling pathway, Non-small cell lung cancer, Pathways in cancer, PPAR signaling pathway, Small cell lung cancer, Thyroid cancer) and a process (regulation of transcription, DNA-dependent). Proteins are expected to have molecular functions (metal ion binding, protein binding, sequence-specific DNA binding, steroid binding and 3 others) and to localizein various compartments (cytoplasm, nucleus). Putative protein interactors have been described (AKAP13, MAP4, NCOA1, NCOA3, NR0B2, NR1H2, NR1H3, NR1I2, NR2C2, NR2E3 and 14 others). 

(From HuGENavigator)

  • Cardiovascular Diseases 
  • Alcoholism 
  • Lung Neoplasms 
  • Prostatic Neoplasms 
  • Schizophrenia 
  • Systemic Vasculitis 
  • Tonsillitis 
  • Urinary Bladder Neoplasms 
  • Psoriasis 
  • Pulmonary Disease, Chronic Obstructive 
  • Hyperlipidemias 
  • Hypospadias 
  • Abortion, Spontaneous 
  • Lupus Erythematosus, Systemic 
  • Mental Disorders 
  • Metabolic Syndrome X 
  • Neoplasms 
  • Osteoporosis 
  • Alzheimer Disease 
  • Arthritis, Psoriatic 
  • Attention Deficit Disorder with Hyperactivity 
  • Autistic Disorder 
  • Bile Duct Neoplasms 
  • Bipolar Disorder 
  • Cryptorchidism 
  • Diabetes Complications 
  • Diabetes Mellitus, Type 1 
  • Diabetes Mellitus, Type 2 
  • Edema 
  • Gallbladder Neoplasms 
  • Gallstones 

Assay Kits and Services are available from INDIGO Biosciences.

Kits are offered in different assay formats to accommodate researchers’ needs: 3x 32, 1x 96, and 1x 384 assay formats for screening small numbers of test compounds, as well as custom bulk reagents for HTS applications. Assay systems are all inclusive, providing reporter cells, optimized growth media, media for diluting test compounds, a positive-control agonist, luciferase detection reagent, a white assay plate, a detailed protocol, and a protocol quick guide. All kits are shipped on dry ice.

RXRβ Reporter Cells are prepared using INDIGO’s proprietary CryoMite™ process. This cryo-preservation method yields high cell viability post-thaw, and provides the convenience of immediately dispensing healthy, division-competent reporter cells into assay plates. There is no need for intermediate spin-and-wash steps, viability determinations, or cell titer adjustments.

The principle application of this assay product is in the screening of test samples to quantify functional activities, either agonist or antagonist, that they may exert against the human retinoid x receptor. This kit product is an all-inclusive assay system that includes, in addition to RXRβ Reporter Cells, two optimized media for use during cell culture and (optionally) in diluting the test samples, a reference agonist, Luciferase Detection Reagent, a cell culture-ready assay plate, and a detailed protocol.

NR2B2; DAUDI6; RCoR-1; H-2RIIBP

(From Aceview)

The gene contains 16 distinct gt-ag introns. Transcription produces 13 different mRNAs, 10 alternatively spliced variants and 3 unspliced forms. There are 2 probable alternative promotors, 3 non overlapping alternative last exons and 4 validated alternative polyadenylation sites (see the diagram). The mRNAs appear to differ by truncation of the 5′ end, truncation of the 3′ end, presence or absence of 4 cassette exons, overlapping exons with different boundaries, splicing versus retention of 7 introns. 438 bp of this gene are antisense to spliced gene SLC39A7andHSD17B8, raising the possibility of regulated alternate expression. in vivo, despite the fact that they are predicted targets of nonsense mediated mRNA decay (NMD). uORF) initiating at an AUG upstream of the main open reading frame (in variant fAug10). 

image-19_med

(From STRINGS)

KAP13, MAP4, NCOA1, NCOA3, NR0B2, NR1H2, NR1H3, NR1I2, NR2C2, NR2E3 and many others. RXR is a common heterodimer partner for “Type 1” nuclear receptors including the PPARs, RARs, TRs, LXRs etc. See this figure for more information.

(From KEGG)

  • Alitretinoin
  • Bexarotene

(From BioGPS)

209148_at_med