• Exposure to certain munitions compounds is know to alter physiological functions in test organisms, however little is known about their molecular and cellular effects.
  • Several nuclear receptors are regulated by xenobiotic compounds. These nuclear receptors belong to a class of ligand-activated transcription factors that, when heterodimerized with RXRa and bound to their respective DNA binding elements, activate gene transcription.
  • Several cell signaling pathways are also affected by xenobiotics, causing dysfunction of normal cellular function and homeostasis.
  • Whole animal experimentation is time and resource intensive and often generates data that is difficult to interpret
  • An initial screening approach would provide detailed mechanistic information that can then be used to guide further in vitro (cell culture) and in vivo (animal) experiments
  • The objective of this study was to characterize the effects of new and existing munitions compounds on xenobiotic-activated nuclear receptor and transcription factor pathways in order to better identify potential molecular initiating events that may result in toxicity.

To view the full poster click HERE.

Source of publication: ERDC: Engineer Research and Development Center

Author information: David R. Johnson (1); ChooYaw Ang (2); Tanwir Habib (2); & Edward J. Perkins (1)

(1) Environmental Laboratory, US Army Engineer Research and Development Center, Vicksburg, MS
(2) Badger Technical Services, Vicksburg, MS

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