The Use of Toxicogenomics in Chemical Safety Testing

  • Current safety testing is geared to produce and accept descriptive data from high-dose animal studies
    • Interpretation of this information has effectively protected our health and safety for decates; however, hindered by lack of understanding mechanistic information
  • Concern over chemical safety for humans and the environment has led to the goal of better understanding the modes of action (MOA) underlying toxic effects and safety issues
    • Regulator requirements are becoming more concerned about the MOA related to the potential safety issues, MOA can identify biomarkers and predict effects
  • Areas where genomics can influence risk management decisions:
    • Prioritization of chemicals
    • Environmental monitoring at known or potentially contaminated sites
    • Chemical risk assessment
      • Identifying effects of chemicals on critical biological pathways
      • Support MOA in a WOE approach for risk assessments in combination with all other information pertinent for risk management decisions

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Date of publication: 18 October 2016; European Centre for Ecotoxicology and Toxicology of Chemicals

Author information: Amber Goetz (1); Richard Peffer (1); David Cowie (1); Richard Currie (1); & Daniel Minnema (1)

(1) Syngenta Crop Protection, LLC