by Marketing | Jun 11, 2018 | New Publications
ABSTRACT Retinoic acid-related orphan receptor γt (RORγt) has a vital role in the differentiation of T-helper 17 (TH17) cells. Potent and specific RORγt inverse agonists are sought for treating TH17-related diseases such as psoriasis, rheumatoid arthritis, and type 1...
by Marketing | Jun 6, 2018 | New Publications
ABSTRACT The α-eleostearic acid (α-ESA) in bitter melon seed oil (BMSO) is efficiently converted by the body into rumenic acid. The objective of this study was to investigate effects of BMSO on skeletal muscle fiber-type switch and endurance capacity in mice, with or...
by Marketing | May 9, 2018 | New Publications
ABSTRACT Estrogen receptor-beta (ERβ) is a drug target for memory consolidation in postmenopausal women. Herein is reported a series of potent and selective ERβ agonists (SERBAs) with in vivo efficacy that are A–C estrogens, lacking the B and D estrogen rings. The...
by Marketing | Apr 5, 2018 | New Publications
ABSTRACT Small molecule agonism of PPARα represents a promising new avenue for the development of non-invasive treatments for oculovascular diseases like diabetic retinopathy and age-related macular degeneration. Herein we report initial structure–activity...
by Marketing | Mar 22, 2018 | New Publications
ABSTRACT The invention disclosed herein is directed to compounds of Formula I and pharmaceutically acceptable salts thereof, which are useful in the treatment of prostate, breast, colon, pancreatic, human chronic lymphocytic leukemia, acute or chronic myeloid...
by Marketing | Mar 8, 2018 | New Publications
“Scientists have shown that a protein can help deliver many of the benefits associated with endurance exercise.” “If you’ve ever wondered how strenuous exercise translates into better endurance, researchers at the Salk Institute may have your answer. In a study...
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