The following drawings make good additions to seminars and classes or just use them as a quick learning tool. Use freely, but please acknowledge the NR Resource. Any addition or corrections, please contact the NRR
- NR Nomenclature
- NR phylogeny
- Structure of NRs
- DNA Binding domain
- Basic gene expression by NRs
- Transcriptional regulation by NRs
- NR Ligands
- Agonist versus antagonist
- NRs and metabolism summary
- NRs and metabolism Phase 1
- NRs and metabolism Phase 2
- NRs and metabolism Phase 3
- Mechanisms of endocrine disruption
- Mechanism of endocrine disruption
- Mechanism of metabolic desruption
- NRs and cellular metabolites
- NRs and dietary bioactives
- Hepatotoxicity IBIPlot
- NR expression by function
- NR expression by GI and Metabolism
- Reverse Cholesterol Transport and NRs
- Types of NR Ligands
- SHRs Summary
- SHR Mechanism of Action
- SHR Structure
- Conformational Change
- Types of ligands (static)
NR Pathways
- AhR Pathway
- AR Pathway
- CAR Pathway
- FXR Pathway
- LRH-1 Pathway
- LXR Pathway
- PPARα Pathway
- PPARβ/δ Pathway
- PPARɣ Pathway
- PXR Pathway
- Retinoic Acid Receptor Alpha (RARα)
- RORα Receptor
- RXRα Pathway