Drawings

The following drawings make good additions to seminars and classes or just use them as a quick learning tool. Use freely, but please acknowledge the NR Resource. Any addition or corrections, please contact the NRR

: NR Nomenclature

: NR phylogeny

: Structure of NRs

: DNA Binding domain

: Basic gene expression by NRs

: Transcriptional regulation by NRs

: NR Ligands

: Agonist versus antagonist

: NRs and metabolism summary

: NRs and metabolism Phase 1

: NRs and metabolism Phase 2

: NRs and metabolism Phase 3

: Mechanisms of endocrine disruption

: Mechanism of endocrine disruption

: Mechanism of metabolic desruption

: NRs and cellular metabolites

: NRs and dietary bioactives

: Hepatotoxicity IBIPlot

: NR expression by function

: NR expression by GI and Metabolism

: Reverse Cholesterol Transport and NRs

: Types of NR Ligands

: SHRs Summary

: SHR Mechanism of Action

: SHR Structure

: Conformational Change

: Types of ligands (static)

NR Pathways

: AhR Pathway

: AR Pathway

: CAR Pathway

: FXR Pathway

: LRH-1 Pathway

: LXR Pathway

: PPARα Pathway

: PPARβ/δ Pathway

: PPARɣ Pathway

: PXR Pathway

: Retinoic Acid Receptor Alpha (RARα)

: RORα Receptor

: RXRα Pathway