Aliases
bHLHe76
NRR Pathway
Summary
(From RefSeq)
(Note: This is not a nuclear receptor, although it shares many characteristics of the family. AHR is a member of the basis-helix-loop-helix, PAS domain (bHLH-PAS) family.) This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Its ligands included a variety of aromatic hydrocarbons. [provided by RefSeq, Jul 2008]
Function
(From Aceview)
here are�218 articles�specifically referring to this gene in PubMed. Functionally, the gene has been tested for association to�diseases�(Adenocarcinoma; Adenoma; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cell Transformation, Neoplastic; Chloracne; Endometriosis; Esophageal Neoplasms; Genetic Predisposition to Disease and�13 others), proposed to participate in a�pathway�(Ahr Signal Transduction Pathway) and�processes�(positive regulation of RNA polymerase II transcriptional preinitiation complex assembly, positive regulation of transcription, DNA-dependent, prostate gland development). Proteins are expected to have molecular�function�(sequence-specific DNA binding) and to�localize�in cytoplasm. Putative�protein interactors�have been described (AHR, AIP, AR, ARNT, ARNTL, CCNT1_, CUL4B, DAP3, EP300, ESR1 and�21 others).�
Disease
(From HuGENavigator)
Lung Neoplasms�
Breast Neoplasms�
Endometriosis�
Infertility, Male�
Colorectal Neoplasms�
Lymphoma, Non-Hodgkin�
Neoplasms�
Urinary Bladder Neoplasms�
DNA Damage�
Assays
Nervous System Diseases�
Occupational Diseases�
Carcinoma, Squamous Cell�
Alzheimer Disease�
Adenocarcinoma�
Adenoma�
Abnormalities�
Abnormalities�
Autonomic Nervous System Diseases�
Brain Neoplasms�
Carcinoma, Small Cell�
Communicable Diseases�
Coronary Artery Disease�
Cryptorchidism�
Dementia�
Diabetes Complications�
Diabetes Mellitus�
Disease Susceptibility�
Cardiovascular Diseases�
Chronic Disease�
Cleft Lip�
Cleft Palate�
Glioma�
Hypersensitivity�
Hypertension�
Hypospadias�
Macular Degeneration�
Metabolic Syndrome X�
Micronuclei, Chromosome-Defective�
Multiple Myeloma�
Kidney Failure, Chronic�
Laryngeal Neoplasms�
Esophageal Neoplasms�
Oligospermia�
Osteoporosis�
Prostatic Neoplasms�
Pulmonary Disease, Chronic Obstructive�
Sleep Initiation and Maintenance Disorders�
Stomach Neoplasms�
Neuropsychological Tests�
Neurotoxicity Syndromes�
Neoplasms, Second Primary�
Neoplasms, Squamous Cell�
Vitiligo�
Interactions
(From STRINGS)
AHR, AIP, AR, ARNT, ARNTL, CCNT1_, CUL4B, DAP3, EP300, ESR1 and�21 others
Human Isoforms
(From�Aceview)
The gene contains�13 distinct gt-ag introns. Transcription produces�6 different mRNAs, 5 alternatively spliced variants and 1 unspliced form. There are 3 probablealternative promotors, 2 non overlapping alternative last exons and 5 validated�alternative polyadenylation sites�(see the�diagram). The mRNAs appear to differ by truncation of the 5' end, truncation of the 3' end, overlapping exons with different boundaries, splicing versus retention of one intron. 270 bp of this gene�are antisense to spliced gene�loyky, raising the possibility of regulated alternate expression.�Note that mRNA .bAug10 was found�in vivo, although it is a predicted target of�nonsense mediated mRNA decay�(NMD).�
Drug Information
(From KEGG)
None noted
Expression
(From BioGPS)
References