Retinoid X Receptor Gamma (RXRɣ; NR2B3)

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described.

[provided by RefSeq, Jun 2010]

NRR Pathway


Retinoid X Receptor Gamma Structure


(From Structure)


(From Aceview)

There are 43 articles specifically referring to this gene in PubMed. Functionally, the gene has been tested for association to diseases (Adenocarcinoma; Adenoma; Alcoholism; Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Bipolar Disorder; Carcinoma, Non-Small-Cell Lung; Cholesterol, HDL/blood*; Endometrial Hyperplasia; Endometrial Neoplasms and 6 others), proposed to participate in pathways (Adipocytokine signaling pathway, Non-small cell lung cancer, Pathways in cancer, PPAR signaling pathway, Small cell lung cancer, Thyroid cancer) and processes (positive regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent, retinoic acid receptor signaling pathway, skeletal muscle tissue development). Proteins are expected to have molecular functions (metal ion binding, retinoid-X receptor activity, sequence-specific DNA binding, steroid binding and 3 others) and to localize in various compartments (cytoplasm, nucleus). Putative protein interactors have been described (CAMK2B, CHGB, CREBBP, ITGB3BP, JUBANDHAUS4, LRSAM1, MAP4, NCOA6, NCOR2, NR0B2 and 17 others). 

(From HuGENavigator)

  • Obesity 
  • Osteoporosis 
  • Disease Progression 
  • Esophageal Neoplasms 
  • Schizophrenia 
  • Tobacco Use Disorder 
  • Vitamin D Deficiency 
  • HIV Infections 
  • HIV Seropositivity 
  • HIV-Associated Lipodystrophy Syndrome 
  • Hypercholesterolemia 
  • Hypertension 
  • Hypospadias 
  • Inflammation 
  • Insulin Resistance 
  • Mental Disorders 
  • Metabolic Syndrome X 
  • Neoplasms 
  • Acquired Immunodeficiency Syndrome 
  • Adenocarcinoma 
  • Alcoholism 
  • Alzheimer Disease 
  • Attention Deficit Disorder with Hyperactivity 
  • Autistic Disorder 
  • Bipolar Disorder 
  • Carcinoma, Squamous Cell 
  • Cardiovascular Diseases 
  • Cleft Lip 
  • Cleft Palate 
  • Coronary Disease 
  • Cryptorchidism 
  • Diabetes Complications 
  • Diabetes Mellitus, Type 2 
  • Diabetic Retinopathy 

Assay Kits and Services are available from INDIGO Biosciences.

Kits are offered in different assay formats to accommodate researchers’ needs: 3x 32, 1x 96, and 1x 384 assay formats for screening small numbers of test compounds, as well as custom bulk reagents for HTS applications. Assay systems are all inclusive, providing reporter cells, optimized growth media, media for diluting test compounds, a positive-control agonist, luciferase detection reagent, a white assay plate, a detailed protocol, and a protocol quick guide. All kits are shipped on dry ice.

RXRɣ Reporter Cells are prepared using INDIGO’s proprietary CryoMite™ process. This cryo-preservation method yields high cell viability post-thaw, and provides the convenience of immediately dispensing healthy, division-competent reporter cells into assay plates. There is no need for intermediate spin-and-wash steps, viability determinations, or cell titer adjustments.

The principle application of this assay product is in the screening of test samples to quantify functional activities, either agonist or antagonist, that they may exert against the human retinoid x receptor. This kit product is an all-inclusive assay system that includes, in addition to RXRɣ Reporter Cells, two optimized media for use during cell culture and (optionally) in diluting the test samples, a reference agonist, Luciferase Detection Reagent, a cell culture-ready assay plate, and a detailed protocol.


(From Aceview)

The gene contains 11 distinct gt-ag introns. Transcription produces 4 different mRNAs, 3 alternatively spliced variants and 1 unspliced form. There are 2 probable alternative promotors, 2 non overlapping alternative last exons and 4 validated alternative polyadenylation sites (see the diagram). The mRNAs appear to differ by truncation of the 5' end, truncation of the 3' end. Efficacy of translation may be reduced by the presence of a shorter translated product (uORF) initiating at an AUG upstream of the main open reading frame (in variant aAug10, bAug10). 



CAMK2B, CHGB, CREBBP, ITGB3BP, JUBANDHAUS4, LRSAM1, MAP4, NCOA6, NCOR2, NR0B2 and many others. RXR is a common heterodimer partner for “Type 1” nuclear receptors including the PPARs, RARs, TRs, LXRs etc. See this figure for more information.

(From KEGG)

  • Alitretinoin
  • Bexarotene

(From BioGPS)