Nuclear Receptor Resource
  • Home
  • Nuclear Receptors
  • Education
    • General Information
    • Drawings
    • White Papers
    • New Publications
    • Other Resources
    • Newsletter Archive
  • About
    • About NRR
    • About the Editor
    • Sponsor
  • Contact
    • Contact NRR
Select Page

Novel Small Molecule Guanidine Sigma1 Inhibitors for Advanced Prostate Cancer

by Marketing | Apr 4, 2017 | New Publications

ABSTRACT Prostate cancer is the most frequently diagnosed malignancy and the leading cause of cancer related death in men. First line therapy for disseminated disease relies on androgen deprivation, leveraging the addiction of these tumors on androgens for both growth...

Cholesterol synthesis inhibitor RO 48-8071 suppresses transcriptional activity of human estrogen and androgen receptor

by Marketing | Jul 15, 2014 | New Publications

ABSTRACT Breast cancer cells express enzymes that convert cholesterol, the synthetic precursor of steroid hormones, into estrogens and androgens, which then drive breast cancer cell proliferation. In the present study, we sought to determine whether...

Structural Stereochemistry of Androstane Hormones Determines Interactions with Human Androgen, Estrogen, and Glucocorticoids Receptors

by Marketing | Mar 14, 2013 | New Publications

ABSTRACT DHEA, 17α-AED, 17β-AED, and 17β-AET exhibit strong biological activity that has been attributed to androgenic, estrogenic, or antiglucocorticoid activity in vivo and in vitro. This study compared DHEA, 17α-AED, 17β-AED, and 17β-AET for their ability to...

An Automated, Cell-based Platform for the Rapid Detection of Novel Androgen Receptor Modulators

by Marketing | Feb 7, 2012 | New Publications

ABSTRACT The Androgen Receptor (AR) is a member of the family of nuclear receptors responsive to steroid hormones. AR activity is regulated through the binding of androgenic hormones (eg., testosterone and di-hydroxy testosterone). In turn, AR functions to regulate...

Sponsored By

Indigo_Logo_4color INDIGO Biosciences, industry-leading provider of both products and services focused on nuclear receptors.

Join the Mailing List

Sign up to join INDIGO Biosciences mailing list.

Sign Up!

About this site

This website utilizes a wide variety of external resources and databases. This optimizes the simplicity in keeping up-to-date, but it decreases the amount that is "personalized" by the editors of this site, and by you the visitor. Please, take time to add to the weblog or to contact the NRR. We are always looking for contributions, suggestion and words of encouragement

Editor-in-Chief

Jack Vanden Heuvel, PhD
Professor of Molecular Toxicology
Penn State University
Disclaimer: Dr. Vanden Heuvel is CSO of INDIGO Biosciences Inc. and is compensated for his activity.
NRR Nuclear Receptor Resource


© 2016 Nuclear Receptor Resource.
All Rights Reserved