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Novel synthesised flavone derivatives provide significant insight into the structural features required for enhanced anti-proliferative activity

by Marketing | Sep 22, 2016 | New Publications

ABSTRACT With many cancers showing resistance to current chemotherapies, the search for novel anti-cancer agents is attracting considerable attention. Natural flavonoids have been identified as useful leads in such programmes. However, since an in-depth understanding...

Novel synthesised flavone derivatives provide significant insight into the structural features required for enhanced anti-proliferative activity

by Marketing | Jun 9, 2016 | New Publications

ABSTRACT With many cancers showing resistance to current chemotherapies, the search for novel anti-cancer agents is attracting considerable attention. Natural flavonoids have been identified as useful leads in such programmes. However, since an in-depth understanding...

Phytoestrogenic activity of blackcurrant (Ribes nigrum) anthocyanins is mediated through estrogen receptor alpha

by Marketing | Oct 13, 2015 | New Publications

ABSTRACT Blackcurrants (Ribes nigrum L., Grossulariaceae) contain high amounts of anthocyanin polyphenols, which have antioxidant and anti-carcinogenic health benefits. This study analyzed the potential phytoestrogenic effects of blackcurrant extract (BCE) in breast...

Cholesterol synthesis inhibitor RO 48-8071 suppresses transcriptional activity of human estrogen and androgen receptor

by Marketing | Jul 15, 2014 | New Publications

ABSTRACT Breast cancer cells express enzymes that convert cholesterol, the synthetic precursor of steroid hormones, into estrogens and androgens, which then drive breast cancer cell proliferation. In the present study, we sought to determine whether...

Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation

by Marketing | Jul 10, 2014 | New Publications

ABSTRACT The RAR-related orphan receptor gamma t (RORγt) is a nuclear receptor required for generating IL-17–producing CD4+ Th17 T cells, which are essential in host defense and may play key pathogenic roles in autoimmune diseases. Oxysterols elicit profound effects...
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This website utilizes a wide variety of external resources and databases. This optimizes the simplicity in keeping up-to-date, but it decreases the amount that is "personalized" by the editors of this site, and by you the visitor. Please, take time to add to the weblog or to contact the NRR. We are always looking for contributions, suggestion and words of encouragement

Editor-in-Chief

Jack Vanden Heuvel, PhD
Professor of Molecular Toxicology
Penn State University
Disclaimer: Dr. Vanden Heuvel is CSO of INDIGO Biosciences Inc. and is compensated for his activity.
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