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Profiling Drug Activity of Human and Ortholog Xenobiotic-Sensing Receptors: PXR, CAR, AhR, and FXR

by Marketing | Apr 4, 2017 | New Publications

View Full Size Research conducted by: Koji Toyokawa (1), Ewa Maddox (1), Jack Vanden Huevel (1,2), & Bruce Sherf (1) (1) INDIGO Biosciences, Inc., 1981 Pine Hall Rd, State College, PA, USA (2) Center for Molecular Toxicology and Carcinogenesis, 325 Life Sciences...

Differential modulation of FXR activity by chlorophacinone and ivermectin analogs

by Marketing | Oct 20, 2016 | New Publications

ABSTRACT Chemicals that alter normal function of farnesoid X receptor (FXR) have been shown to affect the homeostasis of bile acids, glucose, and lipids. Several structural classes of environmental chemicals and drugs that modulated FXR transactivation were previously...

Effects of Munitions Compounds on Xenobiotic-Activated Nuclear Receptors and Signaling Pathways

by Marketing | Sep 22, 2016 | New Publications

ABSTRACT Exposure to certain munitions compounds is know to alter physiological functions in test organisms, however little is known about their molecular and cellular effects. Several nuclear receptors are regulated by xenobiotic compounds. These nuclear receptors...

Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation

by Marketing | Jul 10, 2014 | New Publications

ABSTRACT The RAR-related orphan receptor gamma t (RORγt) is a nuclear receptor required for generating IL-17–producing CD4+ Th17 T cells, which are essential in host defense and may play key pathogenic roles in autoimmune diseases. Oxysterols elicit profound effects...

Activation of Farnesoid-X-Receptor (FXR) by Bioactive Lipids

by Marketing | Mar 11, 2006 | New Publications

ABSTRACT FXR is a nuclear receptor that has gained a great deal of interest in terms of its biological role and potential as therapeutic target. Activating FXR increases transcription of genes that are geared toward preventing synthesis and uptake and promoting...

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About this site

This website utilizes a wide variety of external resources and databases. This optimizes the simplicity in keeping up-to-date, but it decreases the amount that is "personalized" by the editors of this site, and by you the visitor. Please, take time to add to the weblog or to contact the NRR. We are always looking for contributions, suggestion and words of encouragement

Editor-in-Chief

Jack Vanden Heuvel, PhD
Professor of Molecular Toxicology
Penn State University
Disclaimer: Dr. Vanden Heuvel is CSO of INDIGO Biosciences Inc. and is compensated for his activity.
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