by Marketing | Apr 4, 2017 | New Publications
View Full Size Research conducted by: Koji Toyokawa (1), Ewa Maddox (1), Jack Vanden Huevel (1,2), & Bruce Sherf (1) (1) INDIGO Biosciences, Inc., 1981 Pine Hall Rd, State College, PA, USA (2) Center for Molecular Toxicology and Carcinogenesis, 325 Life Sciences...
by Marketing | Oct 20, 2016 | New Publications
ABSTRACT Chemicals that alter normal function of farnesoid X receptor (FXR) have been shown to affect the homeostasis of bile acids, glucose, and lipids. Several structural classes of environmental chemicals and drugs that modulated FXR transactivation were previously...
by Marketing | Sep 22, 2016 | New Publications
ABSTRACT Exposure to certain munitions compounds is know to alter physiological functions in test organisms, however little is known about their molecular and cellular effects. Several nuclear receptors are regulated by xenobiotic compounds. These nuclear receptors...
by Marketing | Jul 10, 2014 | New Publications
ABSTRACT The RAR-related orphan receptor gamma t (RORγt) is a nuclear receptor required for generating IL-17–producing CD4+ Th17 T cells, which are essential in host defense and may play key pathogenic roles in autoimmune diseases. Oxysterols elicit profound effects...
by Marketing | Mar 11, 2006 | New Publications
ABSTRACT FXR is a nuclear receptor that has gained a great deal of interest in terms of its biological role and potential as therapeutic target. Activating FXR increases transcription of genes that are geared toward preventing synthesis and uptake and promoting...
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