Nuclear Receptor Resource
  • Home
  • Nuclear Receptors
  • Education
    • General Information
    • Drawings
    • White Papers
    • New Publications
    • Other Resources
    • Newsletter Archive
  • About
    • About NRR
    • About the Editor
    • Sponsor
  • Contact
    • Contact NRR
Select Page

Validating the Gene Expression of Clinically Relevant CYP450 Enzymes and Transporters in Human upcyte® Hepatocytes to Develop an In Vitro Predictive Tool for DDI

by Marketing | Apr 4, 2017 | New Publications

View Full Size Research conducted by: Samaar Maalouf (1), Bruce Sherf(1), & Jack Vanden Huevel (1,2) (1) INDIGO Biosciences, Inc., 1981 Pine Hall Road, State College, PA, USA (2) Center for Molecular Toxicology and Carcinogenesis, 325 Life Sciences Building, Penn...

Development and characterization of novel and selective inhibitors of cytochrome P450 CYP26A1, the human liver retinoic acid hydroxylase

by Marketing | Feb 26, 2016 | New Publications

ABSTRACT Cytochrome P450 CYP26 enzymes are responsible for all-trans-retinoic acid (atRA) clearance. Inhibition of CYP26 enzymes will increase endogenous atRA concentrations and is an attractive therapeutic target. However, the selectivity and potency of the existing...

Sponsored By

Indigo_Logo_4color INDIGO Biosciences, industry-leading provider of both products and services focused on nuclear receptors.

Join the Mailing List

Sign up to join INDIGO Biosciences mailing list.

Sign Up!

About this site

This website utilizes a wide variety of external resources and databases. This optimizes the simplicity in keeping up-to-date, but it decreases the amount that is "personalized" by the editors of this site, and by you the visitor. Please, take time to add to the weblog or to contact the NRR. We are always looking for contributions, suggestion and words of encouragement

Editor-in-Chief

Jack Vanden Heuvel, PhD
Professor of Molecular Toxicology
Penn State University
Disclaimer: Dr. Vanden Heuvel is CSO of INDIGO Biosciences Inc. and is compensated for his activity.
NRR Nuclear Receptor Resource


© 2016 Nuclear Receptor Resource.
All Rights Reserved