Nuclear Receptor Resource
  • Home
  • Nuclear Receptors
  • Education
    • General Information
    • Drawings
    • White Papers
    • New Publications
    • Other Resources
    • Newsletter Archive
  • About
    • About NRR
    • About the Editor
    • Sponsor
  • Contact
    • Contact NRR
Select Page

Profiling Drug Activity of Human and Ortholog Xenobiotic-Sensing Receptors: PXR, CAR, AhR, and FXR

by Marketing | Apr 4, 2017 | New Publications

View Full Size Research conducted by: Koji Toyokawa (1), Ewa Maddox (1), Jack Vanden Huevel (1,2), & Bruce Sherf (1) (1) INDIGO Biosciences, Inc., 1981 Pine Hall Rd, State College, PA, USA (2) Center for Molecular Toxicology and Carcinogenesis, 325 Life Sciences...

Species Differences in Pregnane X Receptor Activation: Examination of common laboratory animal species

by Marketing | Jul 19, 2016 | New Publications

ABSTRACT Nuclear receptors (NRs) are ligand-dependent transcription factors found in many species that regulate the expression of important target genes involved in a spectrum of developmental and physiological processes. The ligand binding domain (LBD) of NRs is...

Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors

by Marketing | Jul 27, 2013 | New Publications

 ABSTRACT The bacteriostat triclosan (2,4,4′-trichloro-2′-hydroxydiphenylether) (TCS) decreases rat serum thyroxine via putative nuclear receptor (NR) interaction(s) and subsequent transcriptional up-regulation of hepatic catabolism and clearance. However,...

Sponsored By

Indigo_Logo_4color INDIGO Biosciences, industry-leading provider of both products and services focused on nuclear receptors.

Join the Mailing List

Sign up to join INDIGO Biosciences mailing list.

Sign Up!

About this site

This website utilizes a wide variety of external resources and databases. This optimizes the simplicity in keeping up-to-date, but it decreases the amount that is "personalized" by the editors of this site, and by you the visitor. Please, take time to add to the weblog or to contact the NRR. We are always looking for contributions, suggestion and words of encouragement

Editor-in-Chief

Jack Vanden Heuvel, PhD
Professor of Molecular Toxicology
Penn State University
Disclaimer: Dr. Vanden Heuvel is CSO of INDIGO Biosciences Inc. and is compensated for his activity.
NRR Nuclear Receptor Resource


© 2016 Nuclear Receptor Resource.
All Rights Reserved