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Disruption of Nuclear Receptor Signaling Alters Triphenyl Phosphate-Induced Cardiotoxicity in Zebrafish Embryos

by Marketing | Feb 24, 2018 | New Publications

ABSTRACT Triphenyl phosphate (TPHP) is an unsubstituted aryl phosphate ester used as a flame retardant and plasticizer within the United States. Using zebrafish as a model, the objectives of this study were to rely on (1) mRNA-sequencing to uncover pathways disrupted...

Systems toxicology identifies mechanistic impacts of 2-amino-4,6-dinitrotoluene (2A-DNT) exposure in Northern Bobwhite

by Marketing | Dec 1, 2015 | New Publications

ABSTRACT Background: A systems toxicology investigation comparing and integrating transcriptomic and proteomic results was conducted to develop holistic effects characterizations for the wildlife bird model, Northern bobwhite (Colinus virginianus) dosed with the...

β-apo-13-Carotenone Regulates Retinoid X Receptor Transcriptional Activity Through Tetramerization of the Receptor

by Marketing | Oct 16, 2014 | New Publications

ABSTRACT Retinoid X receptor (RXRα) is activated by 9-cis-retinoic acid (9cRA) and regulates transcription as a homodimer or as a heterodimer with other nuclear receptors. We have previously demonstrated that β-apo-13-carotenone, an eccentric cleavage product of...

Examination of Specificity of Retinoid-like Compounds for Human RXRs, RARs, and RORs

by Marketing | Mar 10, 2013 | New Publications

...

Regulation of inflammatory and lipid metabolism genes by eicosapentaenoic acid-rich oil

by Marketing | May 3, 2012 | New Publications

ABSTRACT Omega-3-PUFAs, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), are associated with prevention of various aspects of metabolic syndrome. In the present studies, the effects of oil rich in EPA on gene expression and activation of nuclear receptors...
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This website utilizes a wide variety of external resources and databases. This optimizes the simplicity in keeping up-to-date, but it decreases the amount that is "personalized" by the editors of this site, and by you the visitor. Please, take time to add to the weblog or to contact the NRR. We are always looking for contributions, suggestion and words of encouragement

Editor-in-Chief

Jack Vanden Heuvel, PhD
Professor of Molecular Toxicology
Penn State University
Disclaimer: Dr. Vanden Heuvel is CSO of INDIGO Biosciences Inc. and is compensated for his activity.
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